Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/4693
DC FieldValueLanguage
dc.contributor.authorCunha, Rodrigo A.-
dc.date.accessioned2008-09-01T14:12:51Z-
dc.date.available2008-09-01T14:12:51Z-
dc.date.issued2008en_US
dc.identifier.citationNeurochemistry International. 52:1-2 (2008) 65-72en_US
dc.identifier.urihttps://hdl.handle.net/10316/4693-
dc.description.abstractAdenosine is a prototypical neuromodulator, which mainly controls excitatory transmission through the activation of widespread inhibitory A1 receptors and synaptically located A2A receptors. It was long thought that the predominant A1 receptor-meditated modulation by endogenous adenosine was a homeostatic process intrinsic to the synapse. New studies indicate that endogenous extracellular adenosine is originated as a consequence of the release of gliotransmitters, namely ATP, which sets a global inhibitory tonus in brain circuits rather than in a single synapse. Thus, this neuron-glia long-range communication can be viewed as a form of non-synaptic transmission (a concept introduced by Professor Sylvester Vizi), designed to reduce noise in a circuit. This neuron-glia-induced adenosine release is also responsible for exacerbating salient information through A1 receptor-mediated heterosynaptic depression, whereby the activation of a particular synapse recruits a neuron-glia network to generate extracellular adenosine that inhibits neighbouring non-tetanised synapses. In parallel, the local activation of facilitatory A2A receptors by adenosine, formed from ATP released only at high frequencies from neuronal vesicles, down-regulates A1 receptors and facilitates plasticity selectively in the tetanised synapse. Thus, upon high-frequency firing of a given pathway, the combined exacerbation of global A1 receptor-mediated inhibition in the circuit (heterosynaptic depression) with the local synaptic activation of A2A receptors in the activated synapse, cooperate to maximise salience between the activated and non-tetanised synapses.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T0B-4P37J9K-1/1/5bffd6691faba4edbd8db550a5bcb70den_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectAdenosineen_US
dc.subjectA1 receptoren_US
dc.subjectA2A receptoren_US
dc.subjectNerve endingen_US
dc.subjectNerve terminalen_US
dc.subjectAstrocyteen_US
dc.subjectSynaptic plasticityen_US
dc.subjectModulationen_US
dc.titleDifferent cellular sources and different roles of adenosine: A1 receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A2A receptor-mediated facilitation of plasticityen_US
dc.typearticleen_US
dc.identifier.doi10.1016/j.neuint.2007.06.026-
item.fulltextCom Texto completo-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypearticle-
item.cerifentitytypePublications-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-2550-6422-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
filee3d89c7cd9a046c8bfb54185ac1e20e8.pdf387.8 kBAdobe PDFView/Open
Show simple item record

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.