Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/4689
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dc.contributor.authorCanas, Paula M.-
dc.contributor.authorDuarte, João M. N.-
dc.contributor.authorRodrigues, Ricardo J.-
dc.contributor.authorKöfalvi, Attila-
dc.contributor.authorCunha, Rodrigo A.-
dc.date.accessioned2008-09-01T14:12:47Z-
dc.date.available2008-09-01T14:12:47Z-
dc.date.issued2008-09-01T14:12:47Z-
dc.identifier.citationNeurobiology of Aging. In Press, Corrected Proof:en_US
dc.identifier.urihttp://hdl.handle.net/10316/4689-
dc.description.abstractDifferent presynaptic neuromodulation systems have been explored as possible targets to manage neurodegenerative diseases. However, most studies used young adult animals whereas neurodegenerative diseases are prevalent in the elderly. Thus, we now explored by Western blot analysis how the density of different presynaptic markers and receptors changes with aging in rat hippocampal synaptosomes (purified nerve terminals). Compared to synaptosomal membranes from 2-month-old rats, the density of presynaptic proteins (synaptophysin or SNAP-25) decreased at 18-24 months. In parallel, markers of glutamatergic terminals (vGluT1 or vGluT2) and cholinergic terminal markers (vAChT) constantly decreased with aging from 12 to 18 months onwards, whereas the densities of GABAergic (vGAT) only decreased after 24 months. Inhibitory A1 and CB1 receptor density tended to decrease with aging, whereas facilitatory mGluR5 and P2Y1 receptor density was roughly constant and facilitatory A2A receptor density increased at 18-24 months. Thus aging causes an imbalance of excitatory versus inhibitory nerve terminal markers and causes a predominant decrease of inhibitory rather than facilitatory presynaptic modulation systems.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T09-4S02T4M-1/1/e64b5e4577dafc00487393f333c02a46en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectNerve terminalsen_US
dc.subjectDensityen_US
dc.subjectAdenosineen_US
dc.subjectMetabotropicen_US
dc.subjectGlutamateen_US
dc.subjectAcetylcholineen_US
dc.subjectSynaptophysinen_US
dc.titleModification upon aging of the density of presynaptic modulation systems in the hippocampusen_US
dc.typearticleen_US
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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