Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45373
Title: The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
Authors: Ferreira, José Augusto 
Gonçalves, Lino 
Naghipoor, Jahed 
Oliveira, Paula de 
Rabczuk, Timon 
Keywords: Absorbable Implants; Antineoplastic Agents; Arteries; Paclitaxel; Plaque, Atherosclerotic; Sirolimus; Drug-Eluting Stents; Models, Theoretical
Issue Date: 2017
Publisher: Elsevier
Project: info:eu-repo/grantAgreement/FCT/5876/147205/PT 
Serial title, monograph or event: Mathematical Biosciences
Volume: 283
Abstract: In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.
URI: http://hdl.handle.net/10316/45373
Other Identifiers: 10.1016/j.mbs.2016.11.005
DOI: 10.1016/j.mbs.2016.11.005
Rights: embargoedAccess
Appears in Collections:I&D CMUC - Artigos em Revistas Internacionais

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