Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45151
DC FieldValueLanguage
dc.contributor.authorTeixeira, Luísa J.-
dc.contributor.authorSeabra, Marta-
dc.contributor.authorReis, Elisa-
dc.contributor.authorCruz, M. Teresa Girão da-
dc.contributor.authorPedroso de Lima, M. Conceição-
dc.contributor.authorPereira, Eulália-
dc.contributor.authorMiranda, M. Adelaide-
dc.contributor.authorMarques, M. Paula M.-
dc.date.accessioned2017-12-15T18:55:06Z-
dc.date.available2017-12-15T18:55:06Z-
dc.date.issued2004-
dc.identifier10.1021/jm0311238-
dc.identifier.urihttp://hdl.handle.net/10316/45151-
dc.description.abstractSeveral polynuclear Pt(II) chelates with biogenic polyamines were synthesized and screened for their potential antiproliferative and cytotoxic activity in different human cancer cell lines. To gather information regarding the structure-activity relationships underlying their biological activity, the complexes studied were designed to differ in geometrical parameters such as the nature of the ligand and the number and chemical environment of the metal centers. Distinct effects were found for different cell lines and different structural characteristics of the complexes; chelates II, III, and IV displayed specificity toward the HeLa and HSC-3 epithelial-type cells, while V, VI, and VII were clearly more effective against the THP-1, MOLT-3, and CCRF-CEM leukemia cell lines. The toxicity of these Pt(II) complexes on noncancer cells was, in all cases, found to be reversed upon drug removal.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectBiogenic Aminespor
dc.subjectCell Line, Tumorpor
dc.subjectDrug Screening Assays, Antitumorpor
dc.subjectHumanspor
dc.subjectOrganoplatinum Compoundspor
dc.subjectStructure-Activity Relationshippor
dc.titleCytotoxic Activity of Metal Complexes of Biogenic Polyamines:  Polynuclear Platinum(II) Chelatespor
dc.typearticle-
degois.publication.firstPage2917por
degois.publication.lastPage2925por
degois.publication.issue11por
degois.publication.titleJournal of Medicinal Chemistrypor
dc.peerreviewedyespor
dc.identifier.doi10.1021/jm0311238por
degois.publication.volume47por
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.researchunitCNC.IBILI-
crisitem.author.orcid0000-0003-2625-2567-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
JMC_04_47.pdf225.64 kBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations

52
checked on May 29, 2020

WEB OF SCIENCETM
Citations

50
checked on Feb 18, 2020

Page view(s)

188
checked on Jul 1, 2020

Download(s)

101
checked on Jul 1, 2020

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.