Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/44868
DC Field | Value | Language |
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dc.contributor.author | Branco, Ana F. | - |
dc.contributor.author | Moreira, Ana C. | - |
dc.contributor.author | Cunha-Oliveira, Teresa | - |
dc.contributor.author | Couto, Renata | - |
dc.contributor.author | Sardão, Vilma A. | - |
dc.contributor.author | Rizvanov, Albert A. | - |
dc.contributor.author | Palotas, Andras | - |
dc.contributor.author | Oliveira, Paulo J. | - |
dc.date.accessioned | 2017-12-10T15:36:21Z | - |
dc.date.available | 2017-12-10T15:36:21Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://hdl.handle.net/10316/44868 | - |
dc.description.abstract | Neuro-hormonal regulation of cardiac function via cathecol-amines results in increased heart rate and contractility. A persistent adrenergic tone, however, is an insult to the heart, affecting its regular homeostasis, altering morphology and gene expression patterns, as well as inducing apoptosis of cardio-myocytes. At the same time as being the main oxygen consumers, mitochondria are also key to the energy production required for the heart to maintain its vital functions and to integrate a series of signaling pathways that define the life and death of the cell. As α-adrenergic receptors (α-AR) orchestrate multiple biochemical events that can either trigger or inhibit cell death, mitochondria can act as a referee in the entire process. In fact, α-AR subtypes α1 and α2 activate various down-stream pathways which differently modulate intracellular calcium levels and production of mitochondrial reactive oxygen species (ROS). The delicate balance between an adaptive (cardio-protective) response resulting in increased contractility and activation of survival pathways, vs. cell death caused by calcium and ROS-induced mitochondrial disruption, along with evidence of their clinical and potential therapeutic translations, are reviewed in this communication. | por |
dc.description.sponsorship | FCT | por |
dc.language.iso | eng | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/117912/PT | por |
dc.relation | PEst-C/SAU/LA0001/ 2013-2014 | por |
dc.relation | CENTRO-07-ST24-FEDER-002008 | por |
dc.rights | openAccess | por |
dc.subject | Animals | por |
dc.subject | Calcium | por |
dc.subject | Catecholamines | por |
dc.subject | Humans | por |
dc.subject | Mitochondria | por |
dc.subject | Myocytes, Cardiac | por |
dc.subject | Reactive Oxygen Species | por |
dc.subject | Receptors, Adrenergic, beta | por |
dc.subject | Signal Transduction | por |
dc.subject | Apoptosis | por |
dc.title | β-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates? | por |
dc.type | article | - |
degois.publication.firstPage | 956 | por |
degois.publication.lastPage | 964 | por |
degois.publication.issue | 10 | por |
degois.publication.title | Current drug targets | por |
dc.relation.publisherversion | http://www.eurekaselect.com/124321/article | por |
dc.peerreviewed | yes | por |
degois.publication.volume | 15 | por |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-7382-0339 | - |
crisitem.author.orcid | 0000-0001-7014-4614 | - |
crisitem.author.orcid | 0000-0002-5201-9948 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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23_Branco et al Curr Drug Targets 2014.pdf | 1.41 MB | Adobe PDF | View/Open |
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