Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/44674
Title: | A 3D Model for Mechanistic Control of Drug Release | Authors: | Ferreira, José Augusto Grassi, M. Gudin͂o, Elias Oliveira, Paula de |
Issue Date: | 2014 | Publisher: | Society for Industrial and Applied Mathematics (SIAM) | Project: | PEst-C/MAT/UI0324/2011 | Serial title, monograph or event: | SIAM Journal on Applied Mathematics | Volume: | 74 | Issue: | 3 | Abstract: | A three-dimensional mathematical model for sorption/desorption by a cylindrical polymeric matrix with dispersed drug is proposed. The model is based on a system of partial differential equations coupled with boundary conditions over a moving boundary. We assume that the penetrant diffuses into a swelling matrix and causes a deformation, which induces a stress-driven diffusion and consequently a non-Fickian mass flux. A physically sound nonlinear dependence between strain and penetrant concentration is considered and introduced in a Boltzmann integral with a kernel computed from a Maxwell--Wiechert model. Numerical simulations show how the mechanistic behavior can have a role in drug delivery design. | URI: | https://hdl.handle.net/10316/44674 | DOI: | 10.1137/130930674 10.1137/130930674 |
Rights: | openAccess |
Appears in Collections: | I&D CMUC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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JAF_MG_EG_PO.pdf | 1.86 MB | Adobe PDF | View/Open |
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