Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/44673
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ferreira, José Augusto | - |
dc.contributor.author | Oliveira, Paula de | - |
dc.contributor.author | Silva, Pascoal | - |
dc.contributor.author | Murta, J. N. | - |
dc.date.accessioned | 2017-11-29T17:19:04Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://hdl.handle.net/10316/44673 | - |
dc.description.abstract | A mathematical model which simulates drug delivery through the cornea, from a therapeutic lens to the anterior chamber of the eye, is proposed. The model consists of three coupled systems of partial differential equations linked by interface conditions: drug diffusion in the therapeutic lens; diffusion and metabolic consumption in the cornea; diffusion, convection and metabolic consumption in the anterior chamber of the eye. The dependence of intraocular pressure on the obstruction of the trabecular mesh and the production rate of aqueous humor by the ciliary body is modeled. The therapeutic effects of drugs that act on the trabecular mesh or on the ciliary body are analysed. Comparisons between topical administration and drug delivery from a therapeutic lens are included. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.relation | PEst-C/MAT/UI0324/2011 | por |
dc.rights | embargoedAccess | - |
dc.title | Numerical simulation of aqueous humor flow: From healthy to pathologic situations | por |
dc.type | article | - |
degois.publication.firstPage | 777 | por |
degois.publication.lastPage | 792 | por |
degois.publication.title | Applied Mathematics and Computation | por |
dc.relation.publisherversion | https://doi.org/10.1016/j.amc.2013.10.070 | por |
dc.peerreviewed | yes | por |
dc.identifier.doi | 10.1016/j.amc.2013.10.070 | por |
dc.identifier.doi | 10.1016/j.amc.2013.10.070 | - |
degois.publication.volume | 226 | por |
dc.date.embargo | 2019-11-29T17:19:04Z | - |
uc.controloAutoridade | Sim | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.researchunit | CMUC - Centre for Mathematics of the University of Coimbra | - |
crisitem.author.researchunit | CMUC - Centre for Mathematics of the University of Coimbra | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-5226-2905 | - |
crisitem.author.orcid | 0000-0001-6634-6651 | - |
crisitem.author.orcid | 0000-0001-8926-5176 | - |
Appears in Collections: | I&D CMUC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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TM_Article.pdf | 690.27 kB | Adobe PDF | View/Open |
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