Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/3860
Title: Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats
Authors: Duarte, João M. N. 
Nogueira, Célia 
Mackie, Ken 
Oliveira, Catarina R. 
Cunha, Rodrigo A. 
Köfalvi, Attila 
Issue Date: 2007
Citation: Experimental Neurology. 204:1 (2007) 479-484
Abstract: In the hippocampus, impaired neurophysiology, compromised neurogenesis, and eventually apoptosis accompany cognitive deficits in insulinopenic (type-1) diabetes (T1D). The underlying pathological mechanisms remain to be defined. The hippocampus has a high density of the cannabinoid type 1 receptor (CB1R), which has been shown to control several brain functions affected by diabetes, such as synaptic plasticity, glucose utilisation, memory consolidation and cognition, and maturation and survival of hippocampal neurons. However, the role of this receptor has not been investigated yet in diabetic encephalopathy. We report now that in the streptozotocin animal model of T1D, the hippocampal densities of CB1R protein and of specific CB1R binding sites are significantly increased both in the nerve terminals and in total membranes (changes between 13% and 38%), whereas CB1R mRNA expression is decreased by 25%, suggesting that CB1Rs might play a role in diabetic encephalopathy.
URI: http://hdl.handle.net/10316/3860
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
filef3097d1fda6c486e9ff5b05c0aa53527.pdf336.51 kBAdobe PDFView/Open
Show full item record

Page view(s) 50

313
checked on Dec 4, 2019

Download(s)

80
checked on Dec 4, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.