Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/27929
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Santos, Kathleen | - |
dc.contributor.author | Laranjo, Mafalda | - |
dc.contributor.author | Abrantes, Ana Margarida | - |
dc.contributor.author | Brito, Ana F. | - |
dc.contributor.author | Gonçalves, Cristina | - |
dc.contributor.author | Ribeiro, Ana Bela Sarmento | - |
dc.contributor.author | Botelho, M. Filomena | - |
dc.contributor.author | Soares, Maria I. L. | - |
dc.contributor.author | Oliveira, Andreia S. R. | - |
dc.contributor.author | Melo, Teresa M. V. D. Pinho e | - |
dc.date.accessioned | 2014-12-16T14:56:27Z | - |
dc.date.available | 2014-12-16T14:56:27Z | - |
dc.date.issued | 2014-05-22 | - |
dc.identifier.citation | SANTOS, Kathleen [et. al] - Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles. "European Journal of Medicinal Chemistry". ISSN 0223-5234. Vol. 79 (2014) p. 273–281 | por |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | https://hdl.handle.net/10316/27929 | - |
dc.description.abstract | Further studies on 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles as anticancer agents against breast cancer are reported, allowing to demonstrate the potential of these compounds for the therapy of the triple-negative breast cancer, the most challenging tumors in clinical practice. These compounds were assayed for their in vitro cytotoxicity on several human breast cancer cell lines (MCF7, HCC1954 and HCC1806 cell lines). Particularly interesting were the results obtained for 4-hydroxyphenyl substituted derivative, which proved to be the most promising compound regarding HCC1806 cell line, a triple-negative breast cancer. The effects of the two most active compounds on cell survival, viability, cell cycle, DNA damage and expression of proteins related to cell death pathways were studied. The reported results consolidate the potential of 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles for the therapy of breast cancer, particularly the triple-negative. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.rights | openAccess | por |
dc.subject | 6,7-Bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazole | por |
dc.subject | Antitumor activity | por |
dc.subject | Breast cancer | por |
dc.subject | Triple-negative breast cancer | por |
dc.title | Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles | por |
dc.type | article | por |
degois.publication.firstPage | 273 | por |
degois.publication.lastPage | 281 | por |
degois.publication.title | European Journal of Medicinal Chemistry | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0223523414003274 | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1016/j.ejmech.2014.04.008 | - |
degois.publication.volume | 79 | por |
uc.controloAutoridade | Sim | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0003-0689-6007 | - |
crisitem.author.orcid | 0000-0003-4185-7871 | - |
crisitem.author.orcid | 0000-0002-4142-4841 | - |
crisitem.author.orcid | 0000-0001-7202-1650 | - |
crisitem.author.orcid | 0000-0001-8860-0470 | - |
crisitem.author.orcid | 0000-0003-3256-4954 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais FCTUC Química - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Targeting triple-negative breast cancer cells.pdf | 1.79 MB | Adobe PDF | View/Open |
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