Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/27929
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dc.contributor.authorSantos, Kathleen-
dc.contributor.authorLaranjo, Mafalda-
dc.contributor.authorAbrantes, Ana Margarida-
dc.contributor.authorBrito, Ana F.-
dc.contributor.authorGonçalves, Cristina-
dc.contributor.authorRibeiro, Ana Bela Sarmento-
dc.contributor.authorBotelho, M. Filomena-
dc.contributor.authorSoares, Maria I. L.-
dc.contributor.authorOliveira, Andreia S. R.-
dc.contributor.authorMelo, Teresa M. V. D. Pinho e-
dc.date.accessioned2014-12-16T14:56:27Z-
dc.date.available2014-12-16T14:56:27Z-
dc.date.issued2014-05-22-
dc.identifier.citationSANTOS, Kathleen [et. al] - Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles. "European Journal of Medicinal Chemistry". ISSN 0223-5234. Vol. 79 (2014) p. 273–281por
dc.identifier.issn0223-5234-
dc.identifier.urihttp://hdl.handle.net/10316/27929-
dc.description.abstractFurther studies on 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles as anticancer agents against breast cancer are reported, allowing to demonstrate the potential of these compounds for the therapy of the triple-negative breast cancer, the most challenging tumors in clinical practice. These compounds were assayed for their in vitro cytotoxicity on several human breast cancer cell lines (MCF7, HCC1954 and HCC1806 cell lines). Particularly interesting were the results obtained for 4-hydroxyphenyl substituted derivative, which proved to be the most promising compound regarding HCC1806 cell line, a triple-negative breast cancer. The effects of the two most active compounds on cell survival, viability, cell cycle, DNA damage and expression of proteins related to cell death pathways were studied. The reported results consolidate the potential of 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles for the therapy of breast cancer, particularly the triple-negative.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subject6,7-Bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazolepor
dc.subjectAntitumor activitypor
dc.subjectBreast cancerpor
dc.subjectTriple-negative breast cancerpor
dc.titleTargeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazolespor
dc.typearticlepor
degois.publication.firstPage273por
degois.publication.lastPage281por
degois.publication.titleEuropean Journal of Medicinal Chemistrypor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0223523414003274por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.ejmech.2014.04.008-
degois.publication.volume79por
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextCom Texto completo-
crisitem.author.deptFaculdade de Medicina, Universidade de Coimbra-
crisitem.author.researchunitCNC.IBILI-
crisitem.author.orcid0000-0002-4142-4841-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D IBILI - Artigos em Revistas Internacionais
FCTUC Química - Artigos em Revistas Internacionais
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