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https://hdl.handle.net/10316/2792| Title: | Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors | Authors: | Moreira, Vânia M. A. Vasaitis, Tadas S. Njar, Vincent C. O. Salvador, Jorge A. R. |
Keywords: | Indazole; CYP17; Prostate cancer; Androgen receptor; PC cell lines | Issue Date: | Dec-2007 | Citation: | MOREIRA, Vânia M.A.; VASAITIS, Tadas S.; NJAR, Vincent C.O.; SALVADOR, Jorge A.R. - Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors. Steroids 72:14 (2007) 939-948. | Abstract: | A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines. | URI: | https://hdl.handle.net/10316/2792 | DOI: | 10.1016/j.steroids.2007.08.004 | Rights: | openAccess |
| Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Synthesis and evaluation.pdf | 608.88 kB | Adobe PDF | View/Open |
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