Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/27853
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vieira, Amélia C. F. | - |
dc.contributor.author | Murdan, Sudaxshina | - |
dc.contributor.author | Serra, Arménio C. | - |
dc.contributor.author | Veiga, Francisco J. | - |
dc.contributor.author | Gonsalves, António M. d’A. Rocha | - |
dc.contributor.author | Basit, Abdul W. | - |
dc.date.accessioned | 2014-12-10T12:02:33Z | - |
dc.date.available | 2014-12-10T12:02:33Z | - |
dc.date.issued | 2014-11-04 | - |
dc.identifier.citation | VIEIRA, Amélia C. F. [et. al] - Influence of feeding regimens on rat gut fluids and colonic metabolism of diclofenac-β-cyclodextrin. "Carbohydrate Polymers". ISSN 0144-8617. Vol. 112 (2014) p. 758–764 | por |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.uri | https://hdl.handle.net/10316/27853 | - |
dc.description.abstract | Feeding states may affect the performance of colonic prodrugs. The aim is to investigate the influence of feeding regimen in Wistar rats on: (i) distribution and pH contents along the gut and (ii) metabolism of two colonic prodrugs, diclofenac-β-cyclodextrin and a commercially available control, sulfasalazine, within the caecal and colonic contents. Male Wistar rats were subject to four different feeding regimens, the gut contents characterized (mass and pH) and the metabolism of prodrugs investigated. The feeding regimen affects gut contents (mass and pH), more specifically in the stomach and lower intestine, and affects the rate of metabolism of diclofenac-β-cyclodextrin, but not that of sulfasalazine. The latter's degradation is much faster than that of diclofenac-β-cyclodextrin while the metabolism of both prodrugs is faster in colonic (versus caecal) contents. Fasting results in most rapid degradation of diclofenac-β-cyclodextrin, possibly due to lack of competition (absence of food) for microbial enzymatic activity. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.rights | openAccess | por |
dc.subject | Fasting | por |
dc.subject | Feeding | por |
dc.subject | Regimen | por |
dc.subject | Gastro-intestinal transit | por |
dc.subject | Colonic targeting | por |
dc.subject | Prodrug degradation | por |
dc.title | Influence of feeding regimens on rat gut fluids and colonic metabolism of diclofenac-β-cyclodextrin | por |
dc.type | article | por |
degois.publication.firstPage | 758 | por |
degois.publication.lastPage | 764 | por |
degois.publication.title | Carbohydrate Polymers | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0144861714006407 | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1016/j.carbpol.2014.06.064 | - |
degois.publication.volume | 112 | por |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0001-8664-2757 | - |
crisitem.author.orcid | 0000-0002-1041-0068 | - |
crisitem.author.orcid | 0000-0001-9987-7301 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais I&D CEFarmacêuticos - Artigos em Revistas Internacionais FCTUC Química - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Influence of feeding regimens.pdf | 546.35 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
5
checked on Sep 30, 2024
WEB OF SCIENCETM
Citations
10
5
checked on Oct 2, 2024
Page view(s)
418
checked on Oct 1, 2024
Download(s) 50
471
checked on Oct 1, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.