Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/27853
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dc.contributor.authorVieira, Amélia C. F.-
dc.contributor.authorMurdan, Sudaxshina-
dc.contributor.authorSerra, Arménio C.-
dc.contributor.authorVeiga, Francisco J.-
dc.contributor.authorGonsalves, António M. d’A. Rocha-
dc.contributor.authorBasit, Abdul W.-
dc.date.accessioned2014-12-10T12:02:33Z-
dc.date.available2014-12-10T12:02:33Z-
dc.date.issued2014-11-04-
dc.identifier.citationVIEIRA, Amélia C. F. [et. al] - Influence of feeding regimens on rat gut fluids and colonic metabolism of diclofenac-β-cyclodextrin. "Carbohydrate Polymers". ISSN 0144-8617. Vol. 112 (2014) p. 758–764por
dc.identifier.issn0144-8617-
dc.identifier.urihttps://hdl.handle.net/10316/27853-
dc.description.abstractFeeding states may affect the performance of colonic prodrugs. The aim is to investigate the influence of feeding regimen in Wistar rats on: (i) distribution and pH contents along the gut and (ii) metabolism of two colonic prodrugs, diclofenac-β-cyclodextrin and a commercially available control, sulfasalazine, within the caecal and colonic contents. Male Wistar rats were subject to four different feeding regimens, the gut contents characterized (mass and pH) and the metabolism of prodrugs investigated. The feeding regimen affects gut contents (mass and pH), more specifically in the stomach and lower intestine, and affects the rate of metabolism of diclofenac-β-cyclodextrin, but not that of sulfasalazine. The latter's degradation is much faster than that of diclofenac-β-cyclodextrin while the metabolism of both prodrugs is faster in colonic (versus caecal) contents. Fasting results in most rapid degradation of diclofenac-β-cyclodextrin, possibly due to lack of competition (absence of food) for microbial enzymatic activity.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectFastingpor
dc.subjectFeedingpor
dc.subjectRegimenpor
dc.subjectGastro-intestinal transitpor
dc.subjectColonic targetingpor
dc.subjectProdrug degradationpor
dc.titleInfluence of feeding regimens on rat gut fluids and colonic metabolism of diclofenac-β-cyclodextrinpor
dc.typearticlepor
degois.publication.firstPage758por
degois.publication.lastPage764por
degois.publication.titleCarbohydrate Polymerspor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0144861714006407por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.carbpol.2014.06.064-
degois.publication.volume112por
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0001-8664-2757-
crisitem.author.orcid0000-0002-1041-0068-
crisitem.author.orcid0000-0001-9987-7301-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
I&D CEFarmacêuticos - Artigos em Revistas Internacionais
FCTUC Química - Artigos em Revistas Internacionais
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