Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/27852
DC Field | Value | Language |
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dc.contributor.author | Ribeiro, Márcio | - |
dc.contributor.author | Rosenstock, Tatiana R. | - |
dc.contributor.author | Oliveira, Ana M. | - |
dc.contributor.author | Oliveira, Catarina R. | - |
dc.contributor.author | Rego, A. Cristina | - |
dc.date.accessioned | 2014-12-10T11:47:37Z | - |
dc.date.available | 2014-12-10T11:47:37Z | - |
dc.date.issued | 2014-09 | - |
dc.identifier.citation | RIBEIRO, Márcio [et. al] - Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells. "Free Radical Biology and Medicine". ISSN 0891-5849. Vol. 74 (2014) p. 129–144 | por |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.uri | https://hdl.handle.net/10316/27852 | - |
dc.description.abstract | Akt, protein kinase B; ARE, antioxidant response element; Erk, extracellular signal-regulated kinase; CBP, CREB-binding protein; CREB, cAMP response-element (CRE) binding protein; CDK, cyclin-dependent kinase; DHE, dihydroethidium; Drp1, dynamin-related protein 1 or dynamin 1-like (DNM1L); GCL, glutamate-cysteine ligase; GCLc, glutamate-cysteine catalytic subunit; GPx, glutathione peroxidase; GSH, glutathione, reduced form; GSSG, glutathione oxidized form; IGF-1, Insulin-like growth factor 1; IGF1R, insulin-like growth factor 1 receptor; IR, insulin receptor; IRS, insulin receptor substrate; H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; HKII, hexokinase type II; HD, Huntington’s disease; HO-1, heme oxygenase; Hsp60, heat shock 60 kDa protein 1 (chaperonin); mHtt, mutant huntingtin; mtDNA, mitochondrial DNA; MT-COII, mitochondrial-encoded cytochrome c oxidase II; mTOR, mammalian target of rapamycin; NDUFS3, NADH dehydrogenase (ubiquinone) Fe–S protein 3, 30 kDa (NADH-coenzyme Q reductase); NQO1, NAD(P)H dehydrogenase [quinone] 1; Nrf2, nuclear factor (erythroid-derived 2)-like 2; PI-3K, phosphatidylinositol 3-kinase; PGC-1α, peroxisome proliferator-activated receptor-γ coactivator 1α; ROS, reactive oxygen species; SDHA, succinate dehydrogenase complex, subunit A, flavoprotein (Fp); SOD, superoxide dismutase; Tfam, transcription factor A, mitochondrial; TMRM, tetramethylrhodamine methyl ester; Tom20, translocase of outer mitochondrial membrane 20 homolog (yeast); Tom40, translocase of outer mitochondrial membrane 40 homolog (yeast). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.rights | openAccess | por |
dc.subject | Huntington disease | por |
dc.subject | Oxidative stress | por |
dc.subject | Insulin/IGF-1 signaling | por |
dc.subject | Nrf2 | por |
dc.subject | Mitochondria | por |
dc.subject | Reactive oxygen species | por |
dc.subject | Striatal cells | por |
dc.subject | Akt | por |
dc.title | Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells | por |
dc.type | article | por |
degois.publication.firstPage | 129 | por |
degois.publication.lastPage | 144 | por |
degois.publication.title | Free Radical Biology and Medicine | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0891584914002755 | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1016/j.freeradbiomed.2014.06.023 | - |
degois.publication.volume | 74 | por |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-6942-4328 | - |
crisitem.author.orcid | 0000-0003-0700-3776 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Insulin and IGF-1 improve mitochondrial function.pdf | 3.08 MB | Adobe PDF | View/Open |
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