Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/27767
DC FieldValueLanguage
dc.contributor.authorPontinha, A. Dora R.-
dc.contributor.authorLombardo, Caterina M.-
dc.contributor.authorNeidle, Stephen-
dc.contributor.authorBrett, Ana Maria Oliveira-
dc.date.accessioned2014-12-03T11:40:13Z-
dc.date.available2014-12-03T11:40:13Z-
dc.date.issued2015-02-
dc.identifier.citationPONTINHA, A. Dora R. [et. al] - Triazole-linked phenyl derivatives: redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA. "Bioelectrochemistry". ISSN 1567-5394. Vol. 101 (2015) p. 97–105por
dc.identifier.issn1567-5394-
dc.identifier.urihttps://hdl.handle.net/10316/27767-
dc.description.abstractThe redox mechanism of two trisubstituted triazole-linked phenyl derivatives (CL41 and CL42) and a disubstituted triazole-linked phenyl derivative (CL2r50) were studied using cyclic, differential pulse and square wave voltammetry at a glassy carbon electrode. The CL41, CL42 and CL2r50 oxidation is a complex, pH-dependent irreversible process involving the formation of electroactive products that undergo two consecutive reversible oxidation reactions. The DNA interaction with CL41, CL42 and CL2r50 was investigated by differential pulse voltammetry using the dsDNA-electrochemical biosensor and in DNA/trisubstituted triazole incubated solutions. All three trisubstituted triazole-linked phenyl derivatives interacted with dsDNA causing morphological and oxidative damage to the dsDNA structure in a time-dependent manner. The DNA-electrochemical biosensor enabled the detection of oxidative damage to DNA following the occurrence of the 8-oxoGua and/or 2,8-oxoAde oxidation peaks.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectSubstituted triazole-linked phenyl compoundspor
dc.subjectdsDNA electrochemical biosensorpor
dc.subjectVoltammetrypor
dc.subjectGlassy carbon electrodepor
dc.titleTriazole-linked phenyl derivatives: redox mechanisms and in situ electrochemical evaluation of interaction with dsDNApor
dc.typearticlepor
degois.publication.firstPage97por
degois.publication.lastPage105por
degois.publication.titleBioelectrochemistrypor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1567539414001261por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.bioelechem.2014.08.010-
degois.publication.volume101por
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-0400-4645-
crisitem.author.orcid0000-0002-6244-0891-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
Triazole-linked phenyl derivatives.pdf467.51 kBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations

2
checked on Mar 18, 2024

WEB OF SCIENCETM
Citations 10

2
checked on Mar 2, 2024

Page view(s)

282
checked on Mar 26, 2024

Download(s) 50

426
checked on Mar 26, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.