Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/27703
Title: | Polymorphisms in the TNFA and IL6 Genes Represent Risk Factors for Autoimmune Thyroid Disease | Authors: | Durães, Cecília Moreira, Carla S. Alvelos, Inês Mendes, Adélia Santos, Liliana R. Machado, José Carlos Melo, Miguel Esteves, César Neves, Celestino Sobrinho-Simões, Manuel Soares, Paula |
Issue Date: | 15-Aug-2014 | Publisher: | PLOS | Citation: | DURÃES, Cecília [et. al] - Polymorphisms in the TNFA and IL6 Genes Represent Risk Factors for Autoimmune Thyroid Disease. "PLOS one". ISSN 1932-6203. Vol. 9 Nº. 8 (2014) p. e105492 | Serial title, monograph or event: | PLOS one | Volume: | 9 | Issue: | 8 | Abstract: | Background Autoimmune thyroid disease (AITD) comprises diseases including Hashimoto's thyroiditis and Graves' disease, both characterized by reactivity to autoantigens causing, respectively, inflammatory destruction and autoimmune stimulation of the thyroid-stimulating hormone receptor. AITD is the most common thyroid disease and the leading form of autoimmune disease in women. Cytokines are key regulators of the immune and inflammatory responses; therefore, genetic variants at cytokine-encoding genes are potential risk factors for AITD. Methods Polymorphisms in the IL6-174 G/C (rs1800795), TNFA-308 G/A (rs1800629), IL1B-511 C/T (rs16944), and IFNGR1-56 T/C (rs2234711) genes were assessed in a case-control study comprising 420 Hashimoto's thyroiditis patients, 111 Graves' disease patients and 735 unrelated controls from Portugal. Genetic variants were discriminated by real-time PCR using TaqMan SNP genotyping assays. Results A significant association was found between the allele A in TNFA-308 G/A and Hashimoto's thyroiditis, both in the dominant (OR = 1.82, CI = 1.37–2.43, p-value = 4.4×10−5) and log-additive (OR = 1.64, CI = 1.28–2.10, p-value = 8.2×10−5) models. The allele C in IL6-174 G/C is also associated with Hashimoto's thyroiditis, however, only retained significance after multiple testing correction in the log-additive model (OR = 1.28, CI = 1.06–1.54, p-value = 8.9×10−3). The group with Graves' disease also registered a higher frequency of the allele A in TNFA-308 G/A compared with controls both in the dominant (OR = 1.85, CI = 1.19–2.87, p-value = 7.0×10−3) and log-additive (OR = 1.69, CI = 1.17–2.44, p-value = 6.6×10−3) models. The risk for Hashimoto's thyroiditis and Graves' disease increases with the number of risk alleles (OR for two risk alleles is, respectively, 2.27 and 2.59). Conclusions This study reports significant associations of genetic variants in TNFA and IL6 with the risk for AITD, highlighting the relevance of polymorphisms in inflammation-related genes in the etiopathogenesis of AITD. | URI: | https://hdl.handle.net/10316/27703 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0105492 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Polymorphisms in the TNFA.pdf | 201.13 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
33
checked on Aug 19, 2024
WEB OF SCIENCETM
Citations
5
29
checked on Aug 2, 2024
Page view(s) 50
409
checked on Aug 27, 2024
Download(s)
293
checked on Aug 27, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.