Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/27654
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dc.contributor.authorOthman, Moneeb A. K.-
dc.contributor.authorRincic, Martina-
dc.contributor.authorMelo, Joana B.-
dc.contributor.authorCarreira, Isabel M.-
dc.contributor.authorAlhourani, Eyad-
dc.contributor.authorHunstig, Friederike-
dc.contributor.authorGlaser, Anita-
dc.contributor.authorLiehr, Thomas-
dc.date.accessioned2014-11-17T14:15:58Z-
dc.date.available2014-11-17T14:15:58Z-
dc.date.issued2014-
dc.identifier.citationOTHMAN, Moneeb A. K. [et. al] - A Novel Cryptic Three-Way Translocation t(2;9;18)(p23.2;p21.3;q21.33) with Deletion of Tumor Suppressor Genes in 9p21.3 and 13q14 in a T-Cell Acute Lymphoblastic Leukemia. "Leukemia Research and Treatment". ISSN 2090-3227. (2014)por
dc.identifier.issn2090-3227-
dc.identifier.urihttps://hdl.handle.net/10316/27654-
dc.description.abstractAcute leukemia often presents with pure chromosomal resolution; thus, aberrations may not be detected by banding cytogenetics. Here, a case of 26-year-old male diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) and a normal karyotype after standard GTG-banding was studied retrospectively in detail by molecular cytogenetic and molecular approaches. Besides fluorescence in situ hybridization (FISH), multiplex ligation-dependent probe amplification (MLPA) and high resolution array-comparative genomic hybridization (aCGH) were applied. Thus, cryptic chromosomal aberrations not observed before were detected: three chromosomes were involved in a cytogenetically balanced occurring translocation t(2;9;18)(p23.2;p21.3;q21.33). Besides a translocation t(10;14)(q24;q11) was identified, an aberration known to be common in T-ALL. Due to the three-way translocation deletion of tumor suppressor genes CDKN2A/INK4A/p16, CDKN2B/INK4B/p15, and MTAP/ARF/p14 in 9p21.3 took place. Additionally RB1 in 13q14 was deleted. This patient, considered to have a normal karyotype after low resolution banding cytogenetics, was treated according to general protocol of anticancer therapy (ALL-BFM 95).por
dc.language.isoengpor
dc.publisherHindawi Publishing Corporationpor
dc.rightsopenAccesspor
dc.titleA Novel Cryptic Three-Way Translocation t(2;9;18)(p23.2;p21.3;q21.33) with Deletion of Tumor Suppressor Genes in 9p21.3 and 13q14 in a T-Cell Acute Lymphoblastic Leukemiapor
dc.typearticlepor
degois.publication.titleLeukemia Research and Treatmentpor
dc.relation.publisherversionhttp://www.hindawi.com/journals/lrt/2014/357123/por
dc.peerreviewedYespor
dc.identifier.doi10.1155/2014/357123-
uc.controloAutoridadeSim-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
crisitem.author.deptFaculty of Medicine-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-5049-2670-
crisitem.author.orcid0000-0001-6842-1707-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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