Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/27651
DC Field | Value | Language |
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dc.contributor.author | Machado, Pedro | - |
dc.contributor.author | Navarro-Compán, Victoria | - |
dc.contributor.author | Landewé, Robert | - |
dc.contributor.author | Gaalen, Floris A. van | - |
dc.contributor.author | Roux, Christian | - |
dc.contributor.author | Heijde, Désirée van der | - |
dc.date.accessioned | 2014-11-17T12:07:43Z | - |
dc.date.available | 2015-11-18T03:00:08Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | MACHADO, Pedro [et. al] - How to calculate the ASDAS if the conventional CRP is below the limit of detection or if using high sensitivity CRP? – An analysis in the DESIR cohort. "Arthritis & Rheumatology". ISSN 2326-5205. (2014) | por |
dc.identifier.issn | 2326-5205 | - |
dc.identifier.uri | https://hdl.handle.net/10316/27651 | - |
dc.description.abstract | Background: The Ankylosing Spondylitis Disease Activity Score (ASDAS) is a composite measure of disease activity in axial spondyloarthritis. Objectives: Our aims were to investigate the most appropriate ASDAS-C-reactive protein (ASDAS-CRP) calculation method when the conventional CRP (cCRP) is below the limit of detection, to study the arithmetic influence of low CRP values obtained by high sensitivity CRP (hsCRP) in ASDAS-CRP results and to test agreement between different ASDAS formulae. Methods: Patients with axial spondyloarthritis and cCRP below the limit of detection (5mg/L, n=257) were selected. ASDAS-cCRP was calculated using eleven imputation strategies for the cCRP (range 0-5, at 0.5 intervals). ASDAS-hsCRP and ASDAS-ESR were also calculated. Agreement between ASDAS formulae was tested. Results: ASDAS-CRP calculated with the cCRP imputation values of 1.5 and 2.0mg/L and ASDAS-erythrocyte sedimentation rate (ESR) had better agreement with ASDAS-hsCRP than other imputed formulae. Disagreement was mainly in lower disease activity states (inactive/moderate disease activity). When the CRP value is <2mg/L, the CRP component of the ASDAS-CRP formula can take very low values that may result in inappropriately low ASDAS-CRP values. Conclusion: When the cCRP is below the limit of detection or when the hsCRP is <2mg/L, the constant value of 2mg/L should be used to calculate ASDAS-CRP. There is good agreement between ASDAS-hsCRP and ASDAS-ESR; however, formulae are not interchangeable. | por |
dc.language.iso | eng | por |
dc.publisher | American College of Rheumatology | por |
dc.rights | embargoedAccess | por |
dc.title | How to calculate the ASDAS if the conventional CRP is below the limit of detection or if using high sensitivity CRP? – An analysis in the DESIR cohort | por |
dc.type | article | por |
degois.publication.title | Arthritis & Rheumatology | por |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/art.38921/abstract | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1002/art.38921 | - |
item.openairetype | article | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.orcid | 0000-0002-8411-7972 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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How to calculate the ASDAS.pdf | 609.98 kB | Adobe PDF | View/Open |
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