Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/27408
Title: Long term cortical plasticity in visual retinotopic areas in humans with silent retinal ganglion cell loss
Authors: d' Almeida, Otília C. 
Mateus, Catarina 
Reis, Aldina 
Grazina, Manuela M. 
Castelo-Branco, Miguel 
Keywords: Cortical plasticity; Visual loss; Retinotopic visual areas; Ganglion cells; Development; Mitochondrial gene mutations
Issue Date: 1-Nov-2013
Publisher: Elsevier
Citation: d'ALMEIDA, Otília C. [et. al] - Long term cortical plasticity in visual retinotopic areas in humans with silent retinal ganglion cell loss. "NeuroImage". ISSN 1053-8119. Vol. 81 (2013) p. 222-230
Serial title, monograph or event: NeuroImage
Volume: 81
Abstract: Visual cortical plasticity induced by overt retinal lesions (scotomas) has remained a controversial phenomenon. Here we studied cortical plasticity in a silent model of retinal ganglion cell loss, documented by in vivo optical biopsy using coherence tomography. The cortical impact of non-scotomatous subtle retinal ganglion cell functional and structural loss was investigated in carriers of the mitochondrial DNA 11778G > A mutation causing Leber's hereditary optic neuropathy. We used magnetic resonance imaging (MRI) to measure cortical thickness and fMRI to define retinotopic cortical visual areas V1, V2 and V3 in silent carriers and matched control groups. Repeated Measures analysis of variance revealed a surprising increase in cortical thickness in the younger carrier group (below 21 years of age). This effect dominated in extrastriate cortex, and notably V2. This form of structural plasticity suggests enhanced plastic developmental mechanisms in extrastriate retinotopic regions close to V1 and not receiving direct retinocortical input.
URI: http://hdl.handle.net/10316/27408
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2013.05.032
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
I&D IBILI - Artigos em Revistas Internacionais

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