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|Title:||Long term cortical plasticity in visual retinotopic areas in humans with silent retinal ganglion cell loss||Authors:||d' Almeida, Otília C.
Grazina, Manuela M.
|Keywords:||Cortical plasticity; Visual loss; Retinotopic visual areas; Ganglion cells; Development; Mitochondrial gene mutations||Issue Date:||1-Nov-2013||Publisher:||Elsevier||Citation:||d'ALMEIDA, Otília C. [et. al] - Long term cortical plasticity in visual retinotopic areas in humans with silent retinal ganglion cell loss. "NeuroImage". ISSN 1053-8119. Vol. 81 (2013) p. 222-230||Serial title, monograph or event:||NeuroImage||Volume:||81||Abstract:||Visual cortical plasticity induced by overt retinal lesions (scotomas) has remained a controversial phenomenon. Here we studied cortical plasticity in a silent model of retinal ganglion cell loss, documented by in vivo optical biopsy using coherence tomography. The cortical impact of non-scotomatous subtle retinal ganglion cell functional and structural loss was investigated in carriers of the mitochondrial DNA 11778G > A mutation causing Leber's hereditary optic neuropathy. We used magnetic resonance imaging (MRI) to measure cortical thickness and fMRI to define retinotopic cortical visual areas V1, V2 and V3 in silent carriers and matched control groups. Repeated Measures analysis of variance revealed a surprising increase in cortical thickness in the younger carrier group (below 21 years of age). This effect dominated in extrastriate cortex, and notably V2. This form of structural plasticity suggests enhanced plastic developmental mechanisms in extrastriate retinotopic regions close to V1 and not receiving direct retinocortical input.||URI:||http://hdl.handle.net/10316/27408||ISSN:||1053-8119||DOI:||10.1016/j.neuroimage.2013.05.032||Rights:||openAccess|
|Appears in Collections:||FMUC Medicina - Artigos em Revistas Internacionais|
I&D CNC - Artigos em Revistas Internacionais
I&D IBILI - Artigos em Revistas Internacionais
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