Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/27281
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dc.contributor.authorMontero, Raquel-
dc.contributor.authorGrazina, Manuela-
dc.contributor.authorLópez-Gallardo, Ester-
dc.contributor.authorMontoya, Julio-
dc.contributor.authorBriones, Paz-
dc.contributor.authorNavarro-Sastre, Aleix-
dc.contributor.authorLand, John M.-
dc.contributor.authorHargreaves, Iain P.-
dc.contributor.authorArtuch, Rafael-
dc.contributor.authorO'Callaghan, Maria del Mar-
dc.contributor.authorJou, Cristina-
dc.contributor.authorJimenez, Cecilia-
dc.contributor.authorBuján, Nuria-
dc.contributor.authorPineda, Mercè-
dc.contributor.authorGarcía-Cazorla, Angels-
dc.contributor.authorNascimento, Andrés-
dc.contributor.authorPerez-Dueñas, Belen-
dc.contributor.authorRuiz-Pesini, Eduardo-
dc.contributor.authorFratter, Carl-
dc.contributor.authorSalviati, Leonardo-
dc.contributor.authorSimões, Marta-
dc.contributor.authorMendes, Cândida-
dc.contributor.authorSantos, Maria João-
dc.contributor.authorDiogo, Luísa-
dc.contributor.authorGarcia, Paula-
dc.contributor.authorNavas, Plácido-
dc.date.accessioned2014-10-15T10:05:55Z-
dc.date.available2014-10-15T10:05:55Z-
dc.date.issued2013-07-
dc.identifier.citationMONTERO, Raquel [et. al] - Coenzyme Q10 deficiency in mitochondrial DNA depletion syndromes. "Mitochondrion". ISSN 1567-7249. Vol. 13 Nº. 4 (2013) p. 337-341por
dc.identifier.issn1567-7249-
dc.identifier.urihttps://hdl.handle.net/10316/27281-
dc.description.abstractWe evaluated coenzyme Q10 (CoQ) levels in patients studied under suspicion of mitochondrial DNA depletion syndromes (MDS) (n = 39). CoQ levels were quantified by HPLC, and the percentage of mtDNA depletion by quantitative real-time PCR. A high percentage of MDS patients presented with CoQ deficiency as compared to other mitochondrial patients (Mann–Whitney-U test: p = 0.001). Our findings suggest that MDS are frequently associated with CoQ deficiency, as a possible secondary consequence of disease pathophysiology. Assessment of muscle CoQ status seems advisable in MDS patients since the possibility of CoQ supplementation may then be considered as a candidate therapy.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectMitochondrial DNA depletion syndromepor
dc.subjectCoenzyme Q10 deficiencypor
dc.subjectMitochondrial disorderspor
dc.titleCoenzyme Q10 deficiency in mitochondrial DNA depletion syndromespor
dc.typearticlepor
degois.publication.firstPage337por
degois.publication.lastPage341por
degois.publication.issue4por
degois.publication.titleMitochondrionpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1567724913000640por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.mito.2013.04.001-
degois.publication.volume13por
uc.controloAutoridadeSim-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCIBB - Center for Innovative Biomedicine and Biotechnology-
crisitem.author.orcid0000-0002-1173-6481-
crisitem.author.orcid0000-0002-4018-8787-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
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