Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/27281
Campo DC | Valor | Idioma |
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dc.contributor.author | Montero, Raquel | - |
dc.contributor.author | Grazina, Manuela | - |
dc.contributor.author | López-Gallardo, Ester | - |
dc.contributor.author | Montoya, Julio | - |
dc.contributor.author | Briones, Paz | - |
dc.contributor.author | Navarro-Sastre, Aleix | - |
dc.contributor.author | Land, John M. | - |
dc.contributor.author | Hargreaves, Iain P. | - |
dc.contributor.author | Artuch, Rafael | - |
dc.contributor.author | O'Callaghan, Maria del Mar | - |
dc.contributor.author | Jou, Cristina | - |
dc.contributor.author | Jimenez, Cecilia | - |
dc.contributor.author | Buján, Nuria | - |
dc.contributor.author | Pineda, Mercè | - |
dc.contributor.author | García-Cazorla, Angels | - |
dc.contributor.author | Nascimento, Andrés | - |
dc.contributor.author | Perez-Dueñas, Belen | - |
dc.contributor.author | Ruiz-Pesini, Eduardo | - |
dc.contributor.author | Fratter, Carl | - |
dc.contributor.author | Salviati, Leonardo | - |
dc.contributor.author | Simões, Marta | - |
dc.contributor.author | Mendes, Cândida | - |
dc.contributor.author | Santos, Maria João | - |
dc.contributor.author | Diogo, Luísa | - |
dc.contributor.author | Garcia, Paula | - |
dc.contributor.author | Navas, Plácido | - |
dc.date.accessioned | 2014-10-15T10:05:55Z | - |
dc.date.available | 2014-10-15T10:05:55Z | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | MONTERO, Raquel [et. al] - Coenzyme Q10 deficiency in mitochondrial DNA depletion syndromes. "Mitochondrion". ISSN 1567-7249. Vol. 13 Nº. 4 (2013) p. 337-341 | por |
dc.identifier.issn | 1567-7249 | - |
dc.identifier.uri | https://hdl.handle.net/10316/27281 | - |
dc.description.abstract | We evaluated coenzyme Q10 (CoQ) levels in patients studied under suspicion of mitochondrial DNA depletion syndromes (MDS) (n = 39). CoQ levels were quantified by HPLC, and the percentage of mtDNA depletion by quantitative real-time PCR. A high percentage of MDS patients presented with CoQ deficiency as compared to other mitochondrial patients (Mann–Whitney-U test: p = 0.001). Our findings suggest that MDS are frequently associated with CoQ deficiency, as a possible secondary consequence of disease pathophysiology. Assessment of muscle CoQ status seems advisable in MDS patients since the possibility of CoQ supplementation may then be considered as a candidate therapy. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.rights | openAccess | por |
dc.subject | Mitochondrial DNA depletion syndrome | por |
dc.subject | Coenzyme Q10 deficiency | por |
dc.subject | Mitochondrial disorders | por |
dc.title | Coenzyme Q10 deficiency in mitochondrial DNA depletion syndromes | por |
dc.type | article | por |
degois.publication.firstPage | 337 | por |
degois.publication.lastPage | 341 | por |
degois.publication.issue | 4 | por |
degois.publication.title | Mitochondrion | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S1567724913000640 | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1016/j.mito.2013.04.001 | - |
degois.publication.volume | 13 | por |
uc.controloAutoridade | Sim | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIBB - Center for Innovative Biomedicine and Biotechnology | - |
crisitem.author.orcid | 0000-0002-1173-6481 | - |
crisitem.author.orcid | 0000-0002-4018-8787 | - |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Coenzyme Q10 deficiency in mitochondrial DNA depletion syndromes.pdf | 289.58 kB | Adobe PDF | View/Open |
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