Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/25782
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dc.contributor.authorMoreira, Ana C.-
dc.contributor.authorSilva, Ana M.-
dc.contributor.authorSantos, M. S.-
dc.contributor.authorSardão, Vilma A.-
dc.date.accessioned2014-05-27T11:10:53Z-
dc.date.available2014-05-27T11:10:53Z-
dc.date.issued2013-
dc.identifier.urihttp://hdl.handle.net/10316/25782-
dc.description.abstractResveratrol (3,5,40-trihydroxy-trans stilbene) is commonly recognized by its antioxidant properties. Despite its beneficial qualities, the toxic effects of this natural compound are still unknown. Since mitochondria are essential to support the energy-dependent regulation of several cell functions, the objective of this study was to evaluate resveratrol effects on rat brain and liver mitochondrial fractions from male and females regarding oxidative stress and bioenergetics. No basal differences were observed between mitochondrial fractions from males and females, except in liver mitochondria, the generation of H2O2 by the respiratory chain is lower for female preparations. Resveratrol inhibited lipid peroxidation in preparations from both genders and organs. Furthermore, brain mitochondria in both gender groups appeared susceptible to resveratrol as seen by a decrease in state 3 respiration and alterations in mitochondrial membrane potential fluctuations during ADP phosphorylation. As opposed, liver mitochondria were less affected by resveratrol. Our data also demonstrates that resveratrol inhibits complex I activity in all mitochondrial preparations. The results suggest that brain mitochondria appear to be more susceptible to resveratrol effects, and gender appears to play a minor role. It remains to be determined if resveratrol effects on brain mitochondria contribute to deterioration of mitochondrial function or instead to mediate hormesis-mediated events.por
dc.description.sponsorshipThis work is supported by PTDC/AGR-ALI/108326/2008 to M.S.S. from the Portuguese Foundation for Science and Technology, FEDER/ Compete/National Funds. A.C.M., A.M.S. and V.A.S. are recipient of SFRH/BD/33892/2009, SFRH/BD/76086/2011 and SFRH/BPD/ 31549/2006 fellowships, respectively.por
dc.language.isoengpor
dc.publisherElsevier Ltd.por
dc.rightsopenAccesspor
dc.subjectResveratrolpor
dc.subjectMitochondriapor
dc.subjectBrainpor
dc.subjectLiverpor
dc.subjectToxicologypor
dc.subjectGenderpor
dc.titleResveratrol affects differently rat liver and brain mitochondrial bioenergetics and oxidative stress in vitro: Investigation of the role of genderpor
dc.typearticlepor
degois.publication.firstPage18por
degois.publication.lastPage26por
degois.publication.titleFood and Chemical Toxicologypor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0278691512008381por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.fct.2012.11.031-
degois.publication.volume53por
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitResearch Centre for Anthropology and Health-
crisitem.author.orcid0000-0002-1912-6581-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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