Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/25581
Title: Mitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventions
Authors: Monteiro, João P. 
Oliveira, Paulo J. 
Jurado, A. S. 
Keywords: Mitochondrial membrane lipids; Cardiolipin; Apoptosis; Aging; Pathology
Issue Date: 2013
Publisher: Elsevier Ltd.
Serial title, monograph or event: Progress in Lipid Research
Volume: 52
Issue: 4
Abstract: Mitochondria are arbiters in the fragile balance between cell life and death. These organelles present an intricate membrane system, with a peculiar lipid composition and displaying transverse as well as lateral asymmetry. Some lipids are synthesized inside mitochondria, while others have to be imported or acquired in the form of precursors. Here, we review different processes, including external interventions (e.g., diet) and a range of biological events (apoptosis, disease and aging), which may result in alterations of mitochondrial membrane lipid content. Cardiolipin, the mitochondria lipid trademark, whose biosynthetic pathway is highly regulated, will deserve special attention in this review. The modulation of mitochondrial membrane lipid composition, especially by diet, as a therapeutic strategy for the treatment of some pathologies will be also addressed.
URI: http://hdl.handle.net/10316/25581
DOI: 10.1016/j.plipres.2013.06.002
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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