Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/25476
Title: Immunonephelometry in cyclosporin therapy
Authors: Pereira-Neves, L. 
Ribeiro da Silva, J. 
Prata, L. 
Santos Rosa, M. 
Mota-Pinto, A. 
Keywords: Ciclosporina; Immunonefelometria
Issue Date: 1990
Serial title, monograph or event: Arquivos Portugueses de Oftalmologia
Volume: 1
Issue: 4
Abstract: Cyclosporin is the most effective drug in human allogenic graf survival. Hypertrichosis, gingival hypertrophy, hypertension, hepatotoxicity have been observed but nephrotocicity seems to be the main problem. Cyclosporine activity seems to be related with peripherical lymphocytes, intraocular levels in systemic administration are not effective, and topical treatment appears to be only useful in corneal disease. Cyclosporine blood levels are important to evaluate intestinal absortion, as well as nephrotoxicity is related with blood levels. Aqueous protein levels are related with inflammatory events in uveitis, and can be easily measured in diary clinic by computorized nephelometry; albumin can be a good reference of blood aqueous barrier “in vivo” with alpha antitripsin directly reflecting inflammatory activity. Evaluation of cyclosporin therapy can be done with only one aqueous tap of 50-100ul and measuring 5 proteins at least.
URI: http://hdl.handle.net/10316/25476
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Nacionais

Files in This Item:
File Description SizeFormat
Immunonephelometry in cyclosporin therapy(APO90).pdf2.18 MBAdobe PDFView/Open
Show full item record

Page view(s) 20

539
checked on Jun 9, 2021

Download(s) 50

261
checked on Jun 9, 2021

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.