Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/21649
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dc.contributor.authorNatu, Mădălina V.-
dc.contributor.authorSousa, Hermínio C. de-
dc.contributor.authorGil, Maria H.-
dc.date.accessioned2013-02-14T16:04:09Z-
dc.date.issued2011-
dc.identifier.citationNATU, Mădălina V.; SOUSA, Hermínio C. de; GIL, Maria H. - Electrospun Drug-Eluting Fibers for Biomedical Applications.In ZILBERMAN, Meital, ed. lit. - Active Implants and Scaffolds for Tissue Regeneration. Berlin: Springer, 2011. ISBN 978-3-642-18064-4. p. 57-85-
dc.identifier.isbn978-3-642-18064-4-
dc.identifier.urihttps://hdl.handle.net/10316/21649-
dc.description.abstractElectrospinning is a simple and versatile method to produce fibers using charged polymer solutions. As drug delivery systems, electrospun fibers are an excellent choice because of easy drug entrapment, high surface area, morphology control and biomimetic characteristics. Various drugs and biomolecules can be easily encapsulated inside or on fiber surface either during electrospinning or through post-processing of the fibers. Multicomponent fibers have attracted special attention because new properties and morphologies can be easily obtained through the combination of different polymers. The factors that affect the drug release such as construct geometry and thickness, diameter and porosity, composition, crystallinity, swelling capacity, drug loading, drug state, drug molecular weight, drug solubility in the release medium, drug–polymer–electrospinning solvent interactions are discussed. Mathematical models of drug release from electrospun fibers are reviewed and strategies to attain zero-order release and control of burst stage are considered. Finally, some results concerning release control in bicomponent fibers composed of poly( ε -caprolactone) and Lutrol F127 (poly(oxyethylene-b-oxypropylene-b-oxyethylene) are presented. The properties of the bicomponent fibers were studied in order to determine the effect of electrospinning processing on crystallinity, hydrophilicity and degradation. Acetazolamide and timolol maleate were loaded in the fibers in different concentrations in order to determine the effect of drug solubility in polymer, drug state, drug loading and fiber composition on morphology, drug distribution and release kinetics. Such electrospun drug eluting fibers can be used as basic elements of various implants and scaffolds for tissue regeneration.por
dc.language.isoengpor
dc.publisherSpringer Berlin Heidelbergpor
dc.relation.ispartofseriesStudies in Mechanobiology, Tissue Engineering and Biomaterialspor
dc.relation.ispartofseries8por
dc.rightsopenAccesspor
dc.titleElectrospun Drug-Eluting Fibers for Biomedical Applicationspor
dc.typebookPartpor
degois.publication.firstPage57por
degois.publication.lastPage85por
degois.publication.locationBerlin-
degois.publication.titleActive Implants and Scaffolds for Tissue Regenerationpor
dc.relation.publisherversionhttp://link.springer.com/chapter/10.1007%2F8415_2010_56por
dc.peerreviewedYespor
dc.identifier.doi10.1007/8415_2010_56-
item.openairetypebookPart-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.researchunitCIEPQPF – Chemical Process Engineering and Forest Products Research Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-2629-7805-
Appears in Collections:FCTUC Eng.Química - Livros e Capítulos de Livros
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