Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/13016
DC FieldValueLanguage
dc.contributor.authorBaykal, Asli-
dc.contributor.authorSarigül, Figen-
dc.contributor.authorSüleymanlar, Gültekin-
dc.contributor.authorMoreira, Paula I.-
dc.contributor.authorPerry, George-
dc.contributor.authorSmith, Mark A.-
dc.contributor.authorAlicigüzel, Yakup-
dc.date.accessioned2010-04-19T13:49:07Z-
dc.date.available2010-04-19T13:49:07Z-
dc.date.issued2005-
dc.identifier.citationAmerican Journal of Infectious Diseases. 1:3 (2005) 145-148en_US
dc.identifier.issn1553-6203-
dc.identifier.urihttps://hdl.handle.net/10316/13016-
dc.description.abstractCiprofloxacin, a member of the fluoroquinolone class, is an antibiotic used as a treatment for infections including the Anthrax bacteria. Studies concerning the safety and efficacy of ciprofloxacin have been controversial with respect to nephrotoxicity. Using rats orally treated with ciprofloxacin (400mg/kg/d), the effects of this drug were analyzed measuring several indications of nephrotoxicity: -NAG, creatinine, blood urea nitrogen, and sodium and potassium levels in blood samples. Additionally, histological analyses were performed. -NAG values, a measure of early renal damage, were significantly increased after 4 and 7 days of treatment (p = 0.001 and p = 0.004, respectively) compared with control rats. However, 7 days post-treatment, -NAG values decreased to control levels indicative that adaptive responses were induced to prevent nephrotoxicity. These results indicate that ciprofloxacin in doses comparable to those commonly prescribed does not induce nephrotoxicity. Altogether, they further support the idea that ciprofloxacin can be safely useden_US
dc.language.isoengen_US
dc.publisherScience Publicationsen_US
dc.rightsopenAccessen_US
dc.subjectAntibioticsen_US
dc.subjectNephrotoxicityen_US
dc.subjectRatsen_US
dc.titleCiprofloxacin Does Not Exert Nephrotoxicity in Ratsen_US
dc.typearticleen_US
degois.publication.firstPage145en_US
degois.publication.lastPage148en_US
degois.publication.issue1:3en_US
degois.publication.titleAmerican Journal of Infectious Diseasesen_US
dc.identifier.doi10.3844/ajidsp.2005.145.148-
item.fulltextCom Texto completo-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypearticle-
item.cerifentitytypePublications-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-5177-6747-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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