Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/12777
DC FieldValueLanguage
dc.contributor.authorVieira, Otilia V.-
dc.contributor.authorHartmann, Diego O.-
dc.contributor.authorCardoso, Carla M. P.-
dc.contributor.authorOberdoerfer, Daniel-
dc.contributor.authorBaptista, Marta-
dc.contributor.authorSantos, Manuel A. S.-
dc.contributor.authorAlmeida, Luis-
dc.contributor.authorRamalho-Santos, João:-
dc.date.accessioned2010-03-09T13:05:41Z-
dc.date.available2010-03-09T13:05:41Z-
dc.date.issued2008-08-
dc.identifier.citationPloS One. 3:8 (2008) e2913en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10316/12777-
dc.description.abstractBackground: The urgent need for cheap and easy-to-use protection against both unwanted pregnancies and sexually transmitted diseases has stimulated considerable interest in the use of surfactants as microbicides, anti-viral, and contraceptive agents in recent years. In the present study we report a systematic in vitro evaluation of the microbicidal, anti- viral and contraceptive potential of cationic, anionic, zwitterionic, and non-ionic surfactants. Methodology/Principal Findings: Toxicity was evaluated in mammalian columnar epithelial (MDCK) cells, human sperm cells, Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Streptococcus agalactiae and Enterococcus faecalis. The inhibition of adenovirus and lentivirus infection of MDCK cells was also tested. A homologous series of cationic surfactants, alkyl-N,N,N-trimethylammonium bromides (CnTAB), with varying alkyl chains were shown to be bactericidal and fungicidal at doses that were related to the surfactant critical micelle concentrations (CMC), all of them at concentrations significantly below the CMC. In general, bacteria were more susceptible to this surfactant group than C. albicans and this organism, in turn, was more susceptible than MDCK cells. This suggests that the CnTAB may be useful as vaginal disinfectants only in so far as bacterial and fungal infections are concerned. None of the surfactants examined, including those that have been used in pre-clinical studies, showed inhibition of adenovirus or lentivirus infection of MDCK cells or spermicidal activity at doses that were sub-toxic to MDCK cells. Conclusions/Significance: The results of this study lead us to propose that systematic analysis of surfactant toxicity, such as we report in the present work, be made a mandatory pre-condition for the use of these substances in pre-clinical animal and/or human studiesen_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsopenAccessen_US
dc.titleSurfactants as microbicides and contraceptive agents: a systematic in vitro studyen_US
dc.typearticleen_US
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Farmácia, Universidade de Coimbra-
crisitem.author.researchunitCNC.IBILI-
crisitem.author.researchunitCNC.IBILI-
crisitem.author.orcid0000-0003-4924-1780-
crisitem.author.orcid0000-0001-5831-3307-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais
FCTUC Química - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
Surfactants as Microbicides and Contraceptive Agents.pdf508.13 kBAdobe PDFView/Open
Show simple item record

Page view(s)

153
checked on Jul 30, 2020

Download(s)

79
checked on Jul 30, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.