Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/12669
Title: | A linkage study between the GABAA beta2 and GABAA gamma2 subunit genes and major psychoses | Authors: | Ambrósio, Alda M. Kennedy, James L. Macciardi, Fabio King, Nicole Azevedo, Maria H. Oliveira, Catarina R. Pato, Carlos N. |
Issue Date: | Jan-2005 | Publisher: | MBL Communications, Inc | Citation: | CNS Spectrums. 10:1 (2005) 57-61 | Abstract: | Background: Alterations of the γ-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses. Objective: Restriction fragment length polymorphisms associated with the human γ-aminobutyric acid type A (GABAA) β2 and GABAA γ2 subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses. Methods: Thirty-two schizophrenic families and 25 bipolar families were tested for linkage. Results: Nonparametric linkage (NPL) analysis performed by GENEHUNTER showed no significant NPL scores for both genes in schizophrenia (GABAA β2: NPL narrow=–0.450; NPL broad=–0.808; GABAA γ2: NPL narrow=0.177; NPL broad=–0.051) or bipolar disorder (GABAA β2: NPL narrow=0.834; NPL broad=0.783; GABAA γ2: NPL narrow=–0.159; NPL broad=0.070). Conclusion: Linkage analysis does not support the hypothesis that variants within the GABAA β2 and GABAA γ2 genes are significantly linked to major psychoses in a Portuguese population | URI: | https://hdl.handle.net/10316/12669 | ISSN: | 1092-8529 | DOI: | 10.1017/s1092852900009913 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
A linkage study between the GABAA beta2 and GABAA gamma2.pdf | 179.43 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.