Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/12666
Title: | Investigation and physicochemical characterization of vinpocetine-sulfobutyl ether beta-cyclodextrin binary and ternary complexes | Authors: | Ribeiro, Laura Loftsson, Thorsteinn Ferreira, Domingos Veiga, Francisco |
Keywords: | Sulfobutyl ether b -cyclodextrin; Vinpocetine; Water-soluble polymer; Solubility study; Complexation efficiency; Characterization | Issue Date: | Aug-2003 | Publisher: | The Pharmaceutical Society of Japan | Citation: | Chemical & Pharmaceutical Bulletin. 51:8 (2003) 914-922 | Abstract: | The purpose of this study was to investigate the interactions between vinpocetine (VP), sulfobutyl ether beta-cyclodextrin (SBEbetaCD) and the water-soluble polymers polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC). The water-soluble polymers were shown to improve the complexation efficiency of SBEbetaCD, and thus less SBEbetaCD was needed to prepare solid VP-SBEbetaCD complexes in the presence of the polymers. The interactions between VP and SBEbetaCD, with or without PVP or HPMC, were thoroughly investigated in aqueous solutions using the phase-solubility method as well as in the solid state. The amount of VP solubilized in water or aqueous polymer solution increased linearly with increasing SBEbetaCD concentration, demonstrating A(L)-type plots. We estimated the apparent stability constant (K(c)) at room temperature of VP-SBEbetaCD binary complex to be 340 M(-1) and this value increased to 490 M(-1) or 390 M(-1), respectively, with the addition of PVP and HPMC, assuming a 1 : 1 VP-SBEbetaCD molar ratio. Improvement in the K(c) values for ternary complexes clearly confirmed the benefit of the addition of water-soluble polymers to promote higher complexation efficiency. Solid VP-SBEbetaCD binary and ternary systems were prepared by physical mixing, kneading, coevaporation, and lyophilization methods and fully characterized by scanning electron microscopy, differential scanning calorimetry, and X-ray diffractometry. The results obtained suggest that coevaporation and lyophilization methods yield a higher degree of amorphous entities and indicated formation of VP-SBEbetaCD binary and ternary complexes | URI: | https://hdl.handle.net/10316/12666 | ISSN: | 0009-2363 | DOI: | 10.1248/cpb.51.914 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Investigation and physicochemical characterization of vinpocetine-sulfobutyl ether.pdf | 411.5 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
96
checked on Oct 7, 2024
Page view(s) 50
475
checked on Oct 15, 2024
Download(s)
260
checked on Oct 15, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.