Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/12661
Title: Caveolae as an additional route for influenza virus endocytosis in MDCK cells
Authors: Nunes-Correia, Isabel 
Eulálio, Ana 
Nir, Shlomo 
Lima, Maria C. Pedroso de 
Keywords: Influenza Virus; MDCK Cells; Endocytosis; Clathrin; Caveolae
Issue Date: 2004
Publisher: Polish Society for Cell Biology
Citation: Cellular & Molecular Biology Letters. 9:1 (2004) 47-60
Abstract: Clathrin-mediated endocytosis has been described as the primary internalization pathway for many viruses, including the influenza virus. However, caveolae, an alternative clathrin-independent endocytotic pathway, has also been described as mediating the entry of some molecules, including viruses. To address the question of pathway selection by the influenza virus, we have investigated whether the virus is internalized via clathrin-coated pits and/or caveolae in Madin Darby canine kidney (MDCK) cells. By applying pharmacological manipulations to selectively disrupt the cell internalization pathways, we found that, in MDCK cells, the influenza virus may be internalized via caveolae in addition to entry by clathrin-mediated endocytosis. However, a small contribution by another mode of entry, as recently proposed, cannot be excluded
URI: http://hdl.handle.net/10316/12661
ISSN: 1425-8153
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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