Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/12542
Title: Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high-fat diet
Authors: Sena, C. M. 
Louro, T. 
Matafome, P. 
Nunes, E. 
Monteiro, P. 
Seiça, R. 
Keywords: Endothelium; Nitric Oxide; Diabetes mellitus; Gliclazide; Oxidative stress
Issue Date: Apr-2009
Publisher: Institute of Physiology, Czech Academy of Sciences
Citation: Physiological Research. 58:2 (2009) 203-209
Abstract: Diabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial function in Goto-Kakizaki rats (GK), an animal model of type 2 diabetes fed an atherogenic diet for 4 months. We evaluated the influence of gliclazide on both metabolic and oxidative status and NO-mediated vasodilation. GKAD rats showed increased oxidative stress and impaired endothelium-dependent vasodilation. GKAD rats treated with gliclazide showed increased sensitivity to NO-mediated vasodilation, a significant decrease in fasting glycemia and insulinemia, and a significant decrease in systemic oxidative stress. In conclusion, our results suggest that gliclazide treatment improves NO-mediated vasodilation in diabetic GK rats with dyslipidemia probably due to its antioxidant effects, although we cannot rule out substantial benefits due to a reduction in fasting blood glucose. The availability of a compound that simultaneously decreases hyperglycemia, hyperinsulinemia, and inhibits oxidative stress is a promising therapeutic candidate for the prevention of vascular complications of diabetes
URI: http://hdl.handle.net/10316/12542
ISSN: 0862-8408
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
Antioxidant and vascular effects.pdf755.1 kBAdobe PDFView/Open
Show full item record

Page view(s)

139
checked on Nov 12, 2019

Download(s)

54
checked on Nov 12, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.