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Title: | Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma | Authors: | Magalhães, Mariana Domínguez-Martín, Eva María Jorge, Joana Gonçalves, Ana Cristina Massenzio, Francesca Spigarelli, Renato Ribeiro-Rodrigues, Teresa Catarino, Steve Girão, Henrique Monti, Barbara Spisni, Enzo Ferreira, Lino Oliveira, Paulo J. Efferth, Thomas Rijo, Patrícia Cabral, Célia Margarida dos Santos |
Keywords: | Abietane diterpenes; Antitumor activity; Glioblastoma; Plectranthus hadiensis schweinf.; Royleanone | Issue Date: | 14-Aug-2024 | Publisher: | Elsevier - Journal of Ethnopharmacology | Citation: | Mariana Magalhães, Eva María Domínguez-Martín, Joana Jorge, Ana Cristina Gonçalves, Francesca Massenzio, Renato Spigarelli, Teresa Ribeiro-Rodrigues, Steve Catarino, Henrique Girão, Barbara Monti, Enzo Spisni, Lino Ferreira, Paulo J. Oliveira, Thomas Efferth, Patrícia Rijo, Célia Cabral, Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma, Journal of Ethnopharmacology, Volume 335, 2024, 118689, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2024.118689. | Project: | SFRH/BD/146441/2019 UIDB/04539/2020 info:eu-repo/grantAgreement/UIDP/04539/2020 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA/P/0058/2020/PT SFRH/BD/145531/2019 |
Serial title, monograph or event: | Journal of Ethnopharmacology | Volume: | 335 | Abstract: | Glioblastoma (GB) is the most aggressive and prevalent glioma within the central nervous system. Despite considerable efforts, GB continues to exhibit a dismal 5-year survival rate (∼6%). This is largely attributed to unfavorable prognosis and lack of viable treatment options. Therefore, novel therapies centered around plant-derived compounds emerge as a compelling avenue to enhance patient survival and well-being. The South African species, Plectranthus hadiensis Schweinf. (P. hadiensis), a member of the Lamiaceae family, has a history of use in traditional medicine for treating a range of diseases, including respiratory, digestive, and liver disorders. This species exhibits diverse biological activities, such as anti-inflammatory and antitumoral properties, likely attributed to its rich composition of naturally occurring diterpenes, like the abietane diterpene, 7α-acetoxy-6β-hydroxyroyleanone (Roy). Roy has demonstrated promising antitumor effects in various cancer cell lines, making it a compelling candidate for further investigation into its mechanisms against GB. | URI: | https://hdl.handle.net/10316/116195 | ISSN: | 03788741 | DOI: | 10.1016/j.jep.2024.118689 | Rights: | openAccess |
Appears in Collections: | I&D CIBB - Artigos em Revistas Internacionais |
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