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Title: Cyclodextrin-based dermatological formulations: Dermopharmaceutical and cosmetic applications
Authors: Ferreira, Laura 
Mascarenhas-Melo, Filipa 
Rabaça, Sofia 
Mathur, Ankita
Sharma, Ankur
Giram, Prabhanjan S.
Pawar, Kiran D.
Rahdar, Abbas
Raza, Faisal
Veiga, Francisco 
Mazzola, Priscila Gava
Paiva-Santos, Ana Cláudia 
Keywords: Active ingredient; Cyclodextrin; Cosmetic; Dermopharmaceutical; Skin
Issue Date: Jan-2023
Publisher: Elsevier
Project: PD/BDE/142964/2018 
Serial title, monograph or event: Colloids and Surfaces B: Biointerfaces
Volume: 221
Abstract: The progress in new delivery systems for active ingredients has boosted the dermopharmaceutical and cosmetic fields by allowing formulations to display enhanced skin permeation capabilities. Cyclodextrins (CDs) are cyclic oligosaccharides able to form host-guest inclusion complexes with guest active molecules, resulting in improved physicochemical properties of such molecules. The incorporation of CDs in dermopharmaceutical and cosmetics formulations has received much attention since the late 1970 s by enhancing modulation of the passage through the skin and vectorization into the target site while simultaneously offering a biocompatible delivery system. This paper features the advantages of CDs in dermopharmaceutical and cosmetic applications, such as the improvement of the apparent solubility and the stability of the active ingredients, the possibility of masking unpleasant odors, among others that are be described, emphasizing that these versatile skin active ingredient carriers are strongly promising both in the treatment of skin diseases and in the improvement of cosmetic formulations.
ISSN: 09277765
DOI: 10.1016/j.colsurfb.2022.113012
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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