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Title: miRNA-encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers
Authors: Deka Dey, Asmita
Yousefiasl, Satar
Kumar, Arun
Dabbagh Moghaddam, Farnaz
Rahimmanesh, Ilnaz
Samandari, Mohamadmahdi
Jamwal, Sumit
Maleki, Aziz
Mohammadi, Abbas
Rabiee, Navid
Paiva-Santos, Ana Cláudia 
Tamayol, Ali
Sharifi, Esmaeel
Makvandi, Pooyan
Keywords: abiotic nanomaterials; chronic wounds; miRNA delivery; nanobiovectors; oral mucosa wound; viral and nonviral nanocarriers
Issue Date: Jan-2023
Publisher: Wiley-Blackwell
Serial title, monograph or event: Bioengineering and Translational Medicine
Volume: 8
Issue: 1
Abstract: MicroRNAs (miRNAs) as therapeutic agents have attracted increasing interest in the past decade owing to their significant effectiveness in treating a wide array of ailments. These polymerases II-derived noncoding RNAs act through post-transcriptional controlling of different proteins and their allied pathways. Like other areas of medicine, researchers have utilized miRNAs for managing acute and chronic wounds. The increase in the number of patients suffering from either under-healing or over-healing wound demonstrates the limited efficacy of the current wound healing strategies and dictates the demands for simpler approaches with greater efficacy. Various miRNA can be designed to induce pathway beneficial for wound healing. However, the proper design of miRNA and its delivery system for wound healing applications are still challenging due to their limited stability and intracellular delivery. Therefore, new miRNAs are required to be identified and their delivery strategy needs to be optimized. In this review, we discuss the diverse roles of miRNAs in various stages of wound healing and provide an insight on the most recent findings in the nanotechnology and biomaterials field, which might offer opportunities for the development of new strategies for this chronic condition. We also highlight the advances in biomaterials and delivery systems, emphasizing their challenges and resolutions for miRNA-based wound healing. We further review various biovectors (e.g., adenovirus and lentivirus) and abiotic materials such as organic and inorganic nanomaterials, along with dendrimers and scaffolds, as the delivery systems for miRNA-based wound healing. Finally, challenges and opportunities for translation of miRNA-based strategies into clinical applications are discussed.
ISSN: 2380-6761
DOI: 10.1002/btm2.10343
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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