Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/114620
DC Field | Value | Language |
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dc.contributor.author | Oliveira, Joana Correia | - |
dc.contributor.author | Sousa, Filipa Costa | - |
dc.contributor.author | Campos, Sara Teixeira | - |
dc.contributor.author | Geraldes, Fernanda Bento | - |
dc.contributor.author | Belo, Joana Lopes | - |
dc.contributor.author | Leite, Maria Helena | - |
dc.contributor.author | Mirante, Maria Alice | - |
dc.contributor.author | Águas, Maria Fernanda | - |
dc.date.accessioned | 2024-04-03T08:19:25Z | - |
dc.date.available | 2024-04-03T08:19:25Z | - |
dc.date.issued | 2022-03-22 | - |
dc.identifier.issn | 2543-6767 | pt |
dc.identifier.issn | 0017-0011 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/114620 | - |
dc.description.abstract | Objectives: Analysis of congenital adrenal hyperplasia (CAH) cases, gynaecological implications, referral reasons to gynaecologist and treatment. Material and methods: Retrospective, longitudinal, single-centre study with female CAH paediatric patients ≥ 10 years-old, followed between 1998–2018 in gynaecology and endocrinology departments at a public university tertiary hospital. Results: 47 patients, 34.0% (n = 16) with classic, 66.0% (n = 31) with non-classic forms (NCAH), CYP21 deficit and 46,XX karyotype. We found a normal median menarche age [11.5 IQR 2 (6–15) years-old], but significantly earlier in NCAH (p = 0.003). Precocious puberty occurred in 48.9%, n = 23. Primary amenorrhea occurred in salt-wasting form (21.4%, n = 3). Oligomenorrhea and hirsutism were significantly more prevalent in NCAH (p = 0.018, p = 0.014 respectively) and acanthosis nigricans and virilization signs in classic forms (p = 0.05, p = 0.000 respectively). Sixteen patients (34.0%) were referred to gynaecology, mostly due to menstrual irregularities (50.0%, n = 8). Medical treatment with isolated or combined corticoids, oestrogen and progestogen were chosen in all but one case. Gonadotropin-releasing hormone analogues were used in 19.0% (n = 9). Surgery was performed in 34.0% (n = 16) patients, median age 2.0 IQR 2.5 (0.6–90) years-old. Conclusions: This paper highlights the importance of a multidisciplinary approach. Early treatment contributes to a phenotypical feminine differentiation and normalization of the hypothalamus-pituitary-ovarian axis, which is essential given the gynaecologic and obstetric consequences of untreated cases. | pt |
dc.language.iso | eng | pt |
dc.publisher | Via Medica | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | congenital adrenal hyperplasia | pt |
dc.subject | hyperandrogenism | pt |
dc.subject | steroid 21-hydroxylase | pt |
dc.subject | menstruation disorders | pt |
dc.subject | amenorrhea | pt |
dc.title | Congenital adrenal hyperplasia in adolescence - a gynecological perspective | pt |
dc.type | article | - |
degois.publication.firstPage | 170 | pt |
degois.publication.lastPage | 176 | pt |
degois.publication.issue | 3 | pt |
degois.publication.title | Ginekologia Polska | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.5603/GP.a2021.0248 | pt |
degois.publication.volume | 94 | pt |
dc.date.embargo | 2022-03-22 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Congenital-adrenal-hyperplasia-in-adolescence--a-gynecological-perspectiveGinekologia-Polska.pdf | 238.84 kB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License