Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/114083
DC Field | Value | Language |
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dc.contributor.author | Filgueira, Tayrine Ordonio | - |
dc.contributor.author | Carvalho, Paulo Roberto Cavalcanti | - |
dc.contributor.author | de Sousa Fernandes, Matheus Santos | - |
dc.contributor.author | Castoldi, Angela | - |
dc.contributor.author | Teixeira, Ana | - |
dc.contributor.author | de Albuquerque, Renata Bezerra | - |
dc.contributor.author | de Lima-Filho, José Luiz | - |
dc.contributor.author | Souto, Fabrício Oliveira | - |
dc.date.accessioned | 2024-03-19T10:21:46Z | - |
dc.date.available | 2024-03-19T10:21:46Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1664-3224 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/114083 | - |
dc.description.abstract | COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, which induces a high release of pro-inflammatory chemokines and cytokines, leading to severe systemic disorders. Further, evidence has shown that recovered COVID-19 patients still have some symptoms and disorders from COVID-19. Physical exercise can have many health benefits. It is known to be a potent regulator of the immune system, which includes frequency, intensity, duration, and supervised by a professional. Given the confinement and social isolation or hospitalization of COVID-19 patients, the population became sedentary or opted for physical exercise at home, assuming the guarantee of the beneficial effects of physical exercise and reducing exposure to SARS-CoV-2. This study aimed to investigate the effects of a supervised exercise protocol and a home-based unsupervised exercise protocol on chemokine and cytokine serum levels in recovered COVID-19 patients. This study was a prospective, parallel, two-arm clinical trial. Twenty-four patients who had moderate to severe COVID-19 concluded the intervention protocols of this study. Participants were submitted to either supervised exercise protocol at the Clinical Hospital of the Federal University of Pernambuco or home-based unsupervised exercise for 12 weeks. We analyzed serum levels of chemokines (CXCL8/IL-8, CCL5/RANTES, CXCL9/MIG, CCL2/MCP-1, and CXCL10/IP-10) and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-α, and IFN-γ). Before the interventions, no significant differences were observed in the serum levels of chemokines and cytokines between the supervised and home-based unsupervised exercise groups. The CXCL8/IL-8 (p = 0.04), CCL2/MCP-1 (p = 0.03), and IFN-γ (p = 0.004) levels decreased after 12 weeks of supervised exercise. In parallel, an increase in IL-2 (p = 0.02), IL-6 (p = 0.03), IL-4 (p = 0.006), and IL-10 (p = 0.04) was observed after the supervised protocol compared to pre-intervention levels. No significant differences in all the chemokines and cytokines were found after 12 weeks of the home-based unsupervised exercise protocol. Given the results, the present study observed that supervised exercise was able to modulate the immune response in individuals with post-COVID-19, suggesting that supervised exercise can mitigate the inflammatory process associated with COVID-19 and its disorders. | pt |
dc.language.iso | eng | pt |
dc.publisher | Frontiers Media S.A. | pt |
dc.relation | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) | pt |
dc.relation | CAPES (88887.470105/ 2019-00) | pt |
dc.relation | FACEPE (BFP-0102-1.11/19) | pt |
dc.relation | CNPq (159958/2019-9) | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | supervised exercise protocol | pt |
dc.subject | home-based exercise | pt |
dc.subject | immune biomarkers | pt |
dc.subject | chemokines | pt |
dc.subject | cytokines | pt |
dc.subject | COVID-19 | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Interleukin-10 | pt |
dc.subject.mesh | Interleukin-8 | pt |
dc.subject.mesh | Interleukin-6 | pt |
dc.subject.mesh | Interleukin-4 | pt |
dc.subject.mesh | Interleukin-2 | pt |
dc.subject.mesh | Prospective Studies | pt |
dc.subject.mesh | SARS-CoV-2 | pt |
dc.subject.mesh | Chemokines | pt |
dc.subject.mesh | Cytokines | pt |
dc.subject.mesh | COVID-19 | pt |
dc.title | The impact of supervised physical exercise on chemokines and cytokines in recovered COVID-19 patients | pt |
dc.type | article | - |
degois.publication.firstPage | 1051059 | pt |
degois.publication.title | Frontiers in Immunology | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3389/fimmu.2022.1051059 | pt |
degois.publication.volume | 13 | pt |
dc.date.embargo | 2022-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CIDAF - Research Unit for Sport and Physical Activity | - |
crisitem.author.orcid | 0000-0003-1498-949X | - |
Appears in Collections: | FCDEF - Artigos em Revistas Internacionais |
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The-impact-of-supervised-physical-exercise-on-chemokines-and-cytokines-in-recovered-COVID19-patientsFrontiers-in-Immunology.pdf | 1.1 MB | Adobe PDF | View/Open |
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