Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113949
DC Field | Value | Language |
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dc.contributor.author | Rego, Inês Ramos | - |
dc.contributor.author | Silvério, Daniela | - |
dc.contributor.author | Eufrásio, Maria Isabel | - |
dc.contributor.author | Pinhanços, Sandra Sofia | - |
dc.contributor.author | Lopes da Costa, Bruna | - |
dc.contributor.author | Teixeira, José | - |
dc.contributor.author | Fernandes, Hugo | - |
dc.contributor.author | Kong, Yang | - |
dc.contributor.author | Li, Yao | - |
dc.contributor.author | Tsang, Stephen H | - |
dc.contributor.author | Oliveira, Paulo J. | - |
dc.contributor.author | Fernandes, Rosa | - |
dc.contributor.author | Quinn, Peter M. J. | - |
dc.contributor.author | Santos, P. F. | - |
dc.contributor.author | Ambrósio, António Francisco | - |
dc.contributor.author | Alves, C. Henrique | - |
dc.date.accessioned | 2024-03-12T11:39:06Z | - |
dc.date.available | 2024-03-12T11:39:06Z | - |
dc.date.issued | 2023-02-04 | - |
dc.identifier.issn | 2076-3921 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113949 | - |
dc.description.abstract | Age-related macular degeneration (AMD) is the leading cause of severe vision loss and blindness in elderly people worldwide. The damage to the retinal pigment epithelium (RPE) triggered by oxidative stress plays a central role in the onset and progression of AMD and results from the excessive accumulation of reactive oxygen species (ROS) produced mainly by mitochondria. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial molecular chaperone that contributes to the maintenance of mitochondrial integrity by decreasing the production and accumulation of ROS. The present study aimed to evaluate the presence and the role of TRAP1 in the RPE. Here, we report that TRAP1 is expressed in human adult retinal pigment epithelial cells and is located mainly in the mitochondria. Exposure of RPE cells to hydrogen peroxide decreases the levels of TRAP1. Furthermore, TRAP1 silencing increases intracellular ROS production and decreases mitochondrial respiratory capacity without affecting cell proliferation. Together, these findings offer novel insights into TRAP1 functions in RPE cells, opening possibilities to develop new treatment options for AMD. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | CENTRO-01-0145-FEDER-000008 | pt |
dc.relation | info:eu-repo/grantAgreement/UIDP/04539/2020 | pt |
dc.relation | CEECIND/00886/2017 | pt |
dc.relation | CEECIND/01880/2018 | pt |
dc.relation | CENTRO-01-0145-FEDER-181228 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | age-relatedmacular degeneration (AMD) | pt |
dc.subject | retinal pigment epithelium(RPE) | pt |
dc.subject | mitochondria | pt |
dc.subject | oxidative stress | pt |
dc.subject | tumor necrosis factor receptor-associated protein 1 (TRAP1) | pt |
dc.title | TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status | pt |
dc.type | article | - |
degois.publication.firstPage | 381 | pt |
degois.publication.issue | 2 | pt |
degois.publication.title | Antioxidants | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/antiox12020381 | pt |
degois.publication.volume | 12 | pt |
dc.date.embargo | 2023-02-04 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CIBB - Center for Innovative Biomedicine and Biotechnology | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0002-6152-3468 | - |
crisitem.author.orcid | 0000-0001-7030-0170 | - |
crisitem.author.orcid | 0000-0003-0834-5698 | - |
crisitem.author.orcid | 0000-0002-5201-9948 | - |
crisitem.author.orcid | 0000-0001-7828-2296 | - |
crisitem.author.orcid | 0000-0002-2225-455X | - |
crisitem.author.orcid | 0000-0002-0477-1641 | - |
crisitem.author.orcid | 0000-0001-9776-5701 | - |
Appears in Collections: | I&D CIBB - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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TRAP1-Is-Expressed-in-Human-Retinal-Pigment-Epithelial-Cells-and-Is-Required-to-Maintain-their-Energetic-StatusAntioxidants.pdf | 4.55 MB | Adobe PDF | View/Open |
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