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https://hdl.handle.net/10316/113916
Title: | Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson's Disease | Authors: | Gonçalves, Francisco Q. Matheus, Filipe C. Silva, Henrique B. Real, Joana I. Rial, Daniel Rodrigues, Ricardo J. Oses, Jean-Pierre Silva, Antonio C. Gonçalves, Nélio Prediger, Rui D. Tomé, Ângelo R. Cunha, Rodrigo A. |
Keywords: | Adenosine; Ecto-5′-nucleotidase; A2A receptors; Parkinson’s disease; ATP | Issue Date: | Mar-2023 | Publisher: | Springer Nature | Project: | LCF/PR/HP17/52190001 CENTRO-01–0145-FEDER-000008 CENTRO-01–0246-FEDER-000010 POCI-01–0145- FEDER-03127 UIDB/04539/2020 |
metadata.degois.publication.title: | Molecular Neurobiology | metadata.degois.publication.volume: | 60 | metadata.degois.publication.issue: | 3 | Abstract: | Extracellular ATP can be a danger signal, but its role in striatal circuits afflicted in Parkinson's disease (PD) is unclear and was now investigated. ATP was particularly released at high stimulation intensities from purified striatal nerve terminals of mice, which were endowed with different ATP-P2 receptors (P2R), although P2R antagonists did not alter corticostriatal transmission or plasticity. Instead, ATP was extracellularly catabolized into adenosine through CD73 to activate adenosine A2A receptors (A2AR) modulating corticostriatal long-term potentiation (LTP) in mice. In the presymptomatic phase of a 6-hydroxydopamine rat model of PD, ATP release from striatal nerve terminals was increased and was responsible for a greater impact of CD73 and A2AR on corticostriatal LTP. These observations identify increased ATP release and ATP-derived formation of extracellular adenosine bolstering A2AR activation as a key pathway responsible for abnormal synaptic plasticity in circuits involved in the onset of PD motor symptoms. The translation of these findings to humans prompts extending the use of A2AR antagonists from only co-adjuvants of motor control in Parkinsonian patients to neuroprotective drugs delaying the onset of motor symptoms. | URI: | https://hdl.handle.net/10316/113916 | ISSN: | 0893-7648 1559-1182 |
DOI: | 10.1007/s12035-022-03162-1 | Rights: | openAccess |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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