Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113898
DC Field | Value | Language |
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dc.contributor.author | Sousa, Diana | - |
dc.contributor.author | Sá-Rocha, Mariana | - |
dc.contributor.author | Amaro, Andreia | - |
dc.contributor.author | Ferreira-Junior, Marcos Divino | - |
dc.contributor.author | Cavalcante, Keilah Valéria Naves | - |
dc.contributor.author | Monteiro-Alfredo, Tamaeh | - |
dc.contributor.author | Barra, Cátia | - |
dc.contributor.author | Rosendo-Silva, Daniela | - |
dc.contributor.author | Saavedra, Lucas Paulo Jacinto | - |
dc.contributor.author | Magalhães, José | - |
dc.contributor.author | Caseiro, Armando | - |
dc.contributor.author | Freitas Mathias, Paulo Cezar de | - |
dc.contributor.author | Pereira, Susana P. | - |
dc.contributor.author | Oliveira, Paulo J. | - |
dc.contributor.author | Gomes, Rodrigo Mello | - |
dc.contributor.author | Matafome, Paulo | - |
dc.date.accessioned | 2024-03-08T17:06:35Z | - |
dc.date.available | 2024-03-08T17:06:35Z | - |
dc.date.issued | 2023-03-04 | - |
dc.identifier.issn | 2072-6643 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113898 | - |
dc.description.abstract | Obesogenic environments such as Westernized diets, overnutrition, and exposure to glycation during gestation and lactation can alter peripheral neuroendocrine factors in offspring, predisposing for metabolic diseases in adulthood. Thus, we hypothesized that exposure to obesogenic environments during the perinatal period reprograms offspring energy balance mechanisms. Four rat obesogenic models were studied: maternal diet-induced obesity (DIO); early-life obesity induced by postnatal overfeeding; maternal glycation; and postnatal overfeeding combined with maternal glycation. Metabolic parameters, energy expenditure, and storage pathways in visceral adipose tissue (VAT) and the liver were analyzed. Maternal DIO increased VAT lipogenic [NPY receptor-1 (NPY1R), NPY receptor-2 (NPY2R), and ghrelin receptor], but also lipolytic/catabolic mechanisms [dopamine-1 receptor (D1R) and p-AMP-activated protein kinase (AMPK)] in male offspring, while reducing NPY1R in females. Postnatally overfed male animals only exhibited higher NPY2R levels in VAT, while females also presented NPY1R and NPY2R downregulation. Maternal glycation reduces VAT expandability by decreasing NPY2R in overfed animals. Regarding the liver, D1R was decreased in all obesogenic models, while overfeeding induced fat accumulation in both sexes and glycation the inflammatory infiltration. The VAT response to maternal DIO and overfeeding showed a sexual dysmorphism, and exposure to glycotoxins led to a thin-outside-fat-inside phenotype in overfeeding conditions and impaired energy balance, increasing the metabolic risk in adulthood. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | info:eu-repo/grantAgreement/UIDP/04539/2020 | pt |
dc.relation | LA/P/0058/2020 | pt |
dc.relation | PTDC/DTPDES/ 1082/2014 | pt |
dc.relation | POCI-01-0145-FEDER-016657 | pt |
dc.relation | CENTRO-01-0246-FEDER-000010 | pt |
dc.relation | SFRH/BPD/116061/2016 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | metabolic diseases | pt |
dc.subject | energy balance | pt |
dc.subject | metabolic programming | pt |
dc.subject | sugars and AGEs | pt |
dc.subject | obesity/adipose tissue | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Pregnancy | pt |
dc.subject.mesh | Rats | pt |
dc.subject.mesh | Adipose Tissue | pt |
dc.subject.mesh | Diet, High-Fat | pt |
dc.subject.mesh | Energy Metabolism | pt |
dc.subject.mesh | Liver | pt |
dc.subject.mesh | Obesity | pt |
dc.subject.mesh | Maternal Nutritional Physiological Phenomena | pt |
dc.subject.mesh | Obesity, Maternal | pt |
dc.subject.mesh | Prenatal Exposure Delayed Effects | pt |
dc.title | Exposure to Obesogenic Environments during Perinatal Development Modulates Offspring Energy Balance Pathways in Adipose Tissue and Liver of Rodent Models | pt |
dc.type | article | - |
degois.publication.firstPage | 1281 | pt |
degois.publication.issue | 5 | pt |
degois.publication.title | Nutrients | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/nu15051281 | pt |
degois.publication.volume | 15 | pt |
dc.date.embargo | 2023-03-04 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - Associate Laboratory | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0001-5514-0797 | - |
crisitem.author.orcid | 0000-0002-4276-5920 | - |
crisitem.author.orcid | 0000-0001-7844-0506 | - |
crisitem.author.orcid | 0000-0002-1168-2444 | - |
crisitem.author.orcid | 0000-0002-5201-9948 | - |
crisitem.author.orcid | 0000-0002-3422-290X | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FCTUC Química - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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Exposure-to-Obesogenic-Environments-during-Perinatal-Development-Modulates-Offspring-Energy-Balance-Pathways-in-Adipose-Tissue-and-Liver-of-Rodent-ModelsNutrients.pdf | 9.09 MB | Adobe PDF | View/Open |
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