Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/113780
Title: A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases
Authors: Fernandes, Tânia 
Domingues, M. Rosário M. 
Moreira, Paula I. 
Pereira, Cláudia F. 
Keywords: neurodegenerative disorders; ER–mitochondria contacts; lipid storage; lipophagy; energy production
Issue Date: 8-Mar-2023
Publisher: MDPI
Project: CENTRO-01-0145-FEDER-000012 
POCI-01- 0145-FEDER-028214 
PTDC/MED-NEU/28214/2017 
POCI-01-0145-FEDER-029369 
PTDC/MEDFAR/29369/2017 
UIDB/04539/2020 
info:eu-repo/grantAgreement/UIDP/04539/2020 
EXPL/MED-FSL/0033/2021 
UIDP/50017/2020 
UIDB/50017/2020 
LA/P/0094/2020 
SFRH/BD/148801/2019 
Serial title, monograph or event: Biology
Volume: 12
Issue: 3
Abstract: Mitochondria interact with the endoplasmic reticulum (ER) through contacts called mitochondria-associated membranes (MAMs), which control several processes, such as the ER stress response, mitochondrial and ER dynamics, inflammation, apoptosis, and autophagy. MAMs represent an important platform for transport of non-vesicular phospholipids and cholesterol. Therefore, this region is highly enriched in proteins involved in lipid metabolism, including the enzymes that catalyze esterification of cholesterol into cholesteryl esters (CE) and synthesis of triacylglycerols (TAG) from fatty acids (FAs), which are then stored in lipid droplets (LDs). LDs, through contact with other organelles, prevent the toxic consequences of accumulation of unesterified (free) lipids, including lipotoxicity and oxidative stress, and serve as lipid reservoirs that can be used under multiple metabolic and physiological conditions. The LDs break down by autophagy releases of stored lipids for energy production and synthesis of membrane components and other macromolecules. Pathological lipid deposition and autophagy disruption have both been reported to occur in several neurodegenerative diseases, supporting that lipid metabolism alterations are major players in neurodegeneration. In this review, we discuss the current understanding of MAMs structure and function, focusing on their roles in lipid metabolism and the importance of autophagy in LDs metabolism, as well as the changes that occur in neurogenerative diseases.
URI: https://hdl.handle.net/10316/113780
ISSN: 2079-7737
DOI: 10.3390/biology12030414
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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