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https://hdl.handle.net/10316/113609
Title: | Clinical presentation and management strategies of cardiovascular autonomic dysfunction following a COVID-19 infection - A systematic review | Authors: | Carneiro, Diogo Reis Rocha, Isabel Habek, Mario Helbok, Raimund Sellner, Johann Struhal, Walter Wenning, Gregor Fanciulli, Alessandra |
Keywords: | autonomic nervous system; COVID-19; orthostatic hypotension; postural orthostatic tachycardia syndrome; syncope | Issue Date: | May-2023 | Publisher: | Wiley-Blackwell | Serial title, monograph or event: | European Journal of Neurology | Volume: | 30 | Issue: | 5 | Abstract: | Background: Cardiovascular autonomic dysfunction may reportedly occur after a coronavirus-disease- 2019 (COVID-19) infection, but the available evidence is scattered. Here we sought to understand the acute and mid-term effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) infection on cardiovascular autonomic function. Methods: We performed a systematic PubMed, Embase, Web of Science, medRxiv, and bioRxiv search for cases of cardiovascular autonomic dysfunction during an acute SARS-CoV- 2 infection or post-COVID- 19 condition. The clinical-demographic characteristics of individuals in the acute versus post-COVID- 19 phase were compared. Results: We screened 6470 titles and abstracts. Fifty-four full-length articles were included in the data synthesis. One-hundred and thirty-four cases were identified: 81 during the acute SARS-CoV- 2 infection (24 thereof diagnosed by history) and 53 in the post-COVID- 19 phase. Post-COVID- 19 cases were younger than those with cardiovascular autonomic disturbances in the acute SARS-CoV- 2 phase (42 vs. 51 years old, p = 0.002) and were more frequently women (68% vs. 49%, p = 0.034). Reflex syncope was the most common cardiovascular autonomic disorder in the acute phase (p = 0.008) and postural orthostatic tachycardia syndrome (POTS) the most frequent diagnosis in individuals with post-COVID- 19 orthostatic complaints (p < 0.001). Full recovery was more frequent in individuals with acute versus post-COVID- 19 onset of cardiovascular autonomic disturbances (43% vs. 15%, p = 0.002). Conclusions: There is evidence from the scientific literature about different types of cardiovascular autonomic dysfunction developing during and after COVID-19. More data about the prevalence of autonomic disorders associated with a SARS-CoV- 2 infection are needed to quantify its impact on human health. | URI: | https://hdl.handle.net/10316/113609 | ISSN: | 1351-5101 1468-1331 |
DOI: | 10.1111/ene.15714 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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Euro J of Neurology - 2023 - Reis Carneiro - Clinical presentation and management strategies of cardiovascular autonomic.pdf | 1.87 MB | Adobe PDF | View/Open |
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