Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113490
DC Field | Value | Language |
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dc.contributor.author | Lluís, Núria | - |
dc.contributor.author | Serradilla-Martín, Mario | - |
dc.contributor.author | Achalandabaso, Mar | - |
dc.contributor.author | Jehaes, François | - |
dc.contributor.author | Dasari, Bobby V. M. | - |
dc.contributor.author | Mambrilla-Herrero, Sara | - |
dc.contributor.author | Sparrelid, Ernesto | - |
dc.contributor.author | Balakrishnan, Anita | - |
dc.contributor.author | Hoogwater, Frederik J. H. | - |
dc.contributor.author | Amaral, Maria J. | - |
dc.contributor.author | Andersson, Bodil | - |
dc.contributor.author | Berrevoet, Frederik | - |
dc.contributor.author | Doussot, Alexandre | - |
dc.contributor.author | López-López, Víctor | - |
dc.contributor.author | Alsammani, Mohammedsuror | - |
dc.contributor.author | Detry, Olivier | - |
dc.contributor.author | Domingo-Del Pozo, Carlos | - |
dc.contributor.author | Machairas, Nikolaos | - |
dc.contributor.author | Pekli, Damján | - |
dc.contributor.author | Alcázar-López, Cándido F. | - |
dc.contributor.author | Asbun, Horacio | - |
dc.contributor.author | Björnsson, Bergthor | - |
dc.contributor.author | Christophides, Thalis | - |
dc.contributor.author | Díez-Caballero, Alberto | - |
dc.contributor.author | Francart, David | - |
dc.contributor.author | Noel, Colin B. | - |
dc.contributor.author | Sousa-Silva, Donzília | - |
dc.contributor.author | Toledo-Martínez, Enrique | - |
dc.contributor.author | Tzimas, George N. | - |
dc.contributor.author | Yaqub, Sheraz | - |
dc.contributor.author | Cauchy, François | - |
dc.contributor.author | Prieto-Calvo, Mikel | - |
dc.contributor.author | D'Souza, Melroy A. | - |
dc.contributor.author | Spiers, Harry V. M. | - |
dc.contributor.author | van den Heuvel, Marius C. | - |
dc.contributor.author | Charco, Ramón | - |
dc.contributor.author | Lesurtel, Mickaël | - |
dc.contributor.author | Ramia, José M. | - |
dc.date.accessioned | 2024-02-21T12:07:15Z | - |
dc.date.available | 2024-02-21T12:07:15Z | - |
dc.date.issued | 2023-04-01 | - |
dc.identifier.issn | 1743-9159 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/113490 | - |
dc.description.abstract | Background/Purpose: Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease in Western countries. The main aim of this study was to characterize current surgical strategies and outcomes in the mainly European participating centers. Methods: A multi-institutional retrospective series of patients with a diagnosis of IPNB undergoing surgery between 1 January 2010 and 31 December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association. The textbook outcome (TO) was defined as a non-prolonged length of hospital stay plus the absence of any Clavien–Dindo grade at least III complications, readmission, or mortality within 90 postoperative days. Results: A total of 28 centers contributed 85 patients who underwent surgery for IPNB. The median age was 66 years (55–72), 49.4% were women, and 87.1% were Caucasian. Open surgery was performed in 72 patients (84.7%) and laparoscopic in 13 (15.3%). TO was achieved in 54.1% of patients, reaching 63.8% after liver resection and 32.0% after pancreas resection. Median overall survival was 5.72 years, with 5-year overall survival of 63% (95% CI: 50–82). Overall survival was better in patients with Charlson comorbidity score 4 or less versus more than 4 (P =0.016), intrahepatic versus extrahepatic tumor (P=0.027), single versus multiple tumors (P= 0.007), those who underwent hepatic versus pancreatic resection (P= 0.017), or achieved versus failed TO (P=0.029). Multivariable Cox regression analysis showed that not achieving TO (HR: 4.20; 95% CI: 1.11–15.94; P=0.03) was an independent prognostic factor of poor overall survival. Conclusions: Patients undergoing liver resection for IPNB were more likely to achieve a TO outcome than those requiring a pancreatic resection. Comorbidity, tumor location, and tumor multiplicity influenced overall survival. TO was an independent prognostic factor of overall survival. | pt |
dc.language.iso | eng | pt |
dc.publisher | Wolters Kluwer Health | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | bile duct neoplasms | pt |
dc.subject | intraductal precursor lesion | pt |
dc.subject | pancreas | pt |
dc.subject | surgical resection | pt |
dc.subject | textbook outcome | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Bile Ducts, Intrahepatic | pt |
dc.subject.mesh | Retrospective Studies | pt |
dc.subject.mesh | Bile Ducts | pt |
dc.subject.mesh | Bile Duct Neoplasms | pt |
dc.subject.mesh | Carcinoma, Papillary | pt |
dc.title | Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study) | pt |
dc.type | article | - |
degois.publication.firstPage | 760 | pt |
degois.publication.lastPage | 771 | pt |
degois.publication.issue | 4 | pt |
degois.publication.title | International journal of surgery (London, England) | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1097/JS9.0000000000000280 | pt |
degois.publication.volume | 109 | pt |
dc.date.embargo | 2023-04-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
crisitem.author.orcid | 0000-0002-7494-3218 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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intraductal_papillary_neoplasms_of_the_bile_duct_.13.pdf | 830.07 kB | Adobe PDF | View/Open |
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