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https://hdl.handle.net/10316/113457
Title: | A standardised protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia | Authors: | Santana, Magda M. Gaspar, Laetitia S. Pinto, Maria M. Silva, Patrick Joel da Adão, Diana Pereira, Dina Ribeiro, Joana Afonso Cunha, Inês Huebener-Schmid, Jeannette Raposo, Mafalda Ferreira, Ana F. Faber, Jennifer Kuhs, Sandra Garcia-Moreno, Hector Reetz, Kathrin Thieme, Andreas Infante, Jon van de Warrenburg, Bart P. C. Giunti, Paola Riess, Olaf Schöls, Ludger Lima, Manuela Klockgether, Thomas Januário, Cristina Almeida, Luís Pereira de |
Keywords: | ataxia; biomarkers; blood,; cerebrospinal fluid; neurodegenerative diseases; protocol; research; standardisation | Issue Date: | Apr-2023 | Publisher: | Wiley-Blackwell | Project: | UID/NEU/04539/2019 SFRH/BD/121101/2016 SFRH/BD/148451/2019 |
Serial title, monograph or event: | Neuropathology and Applied Neurobiology | Volume: | 49 | Issue: | 2 | Abstract: | The European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative (ESMI) is a consortium established with the ambition to set up the largest European longitudinal trial-ready cohort of Spinocerebellar Ataxia Type 3/Machado-Joseph Disease (SCA3/MJD), the most common autosomal dominantly inherited ataxia worldwide. A major focus of ESMI has been the identification of SCA3/MJD biomarkers to enable future interventional studies. As biosample collection and processing variables significantly impact the outcomes of biomarkers studies, biosampling procedures standardisation was done previously to study visit initiation. Here, we describe the ESMI consensus biosampling protocol, developed within the scope of ESMI, that ultimately might be translated to other neurodegenerative disorders, particularly ataxias, being the first step to protocol harmonisation in the field. | URI: | https://hdl.handle.net/10316/113457 | ISSN: | 0305-1846 1365-2990 |
DOI: | 10.1111/nan.12892 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Neuropathology Appl Neurobio - 2023 - Santana - A standardised protocol for blood and cerebrospinal fluid collection and.pdf | 2.21 MB | Adobe PDF | View/Open |
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