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Title: Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges
Authors: Sachdeva, Bhuvi
Sachdeva, Punya
Negi, Arvind
Ghosh, Shampa
Han, Sungsoo
Dewanjee, Saikat
Jha, Saurabh Kumar
Bhaskar, Rakesh
Sinha, Jitendra Kumar
Paiva-Santos, Ana Cláudia 
Jha, Niraj Kumar
Kesari, Kavindra Kumar
Keywords: nanoparticles; chitosan; chitin; polysaccharides; nanocarriers; anticancer agents
Issue Date: 28-Mar-2023
Publisher: MDPI
Serial title, monograph or event: Marine Drugs
Volume: 21
Issue: 4
Abstract: Chitin is the second most abundant biopolymer consisting of N-acetylglucosamine units and is primarily derived from the shells of marine crustaceans and the cell walls of organisms (such as bacteria, fungi, and algae). Being a biopolymer, its materialistic properties, such as biodegradability, and biocompatibility, make it a suitable choice for biomedical applications. Similarly, its deacetylated derivative, chitosan, exhibits similar biocompatibility and biodegradability properties, making it a suitable support material for biomedical applications. Furthermore, it has intrinsic material properties such as antioxidant, antibacterial, and antitumor. Population studies have projected nearly 12 million cancer patients across the globe, where most will be suffering from solid tumors. One of the shortcomings of potent anticancer drugs is finding a suitable cellular delivery material or system. Therefore, identifying new drug carriers to achieve effective anticancer therapy is becoming essential. This paper focuses on the strategies implemented using chitin and chitosan biopolymers in drug delivery for cancer treatment.
ISSN: 1660-3397
DOI: 10.3390/md21040211
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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