Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/113377
Title: Self-Renewal and Pluripotency in Osteosarcoma Stem Cells' Chemoresistance: Notch, Hedgehog, and Wnt/β-Catenin Interplay with Embryonic Markers
Authors: Martins-Neves, Sara R. 
Ribeiro, Gabriela Sampaio 
Gomes, Célia M. F. 
Keywords: osteosarcoma; mesenchymal stem cell; cancer stem cell; self-renewal; Notch; Hedgehog; Wnt; pluripotency; SOX-2; KLF4
Issue Date: 7-May-2023
Publisher: MDPI
Project: PTDC/BTM-SAL/4451/2020 
UIDB/04539/2020 
UIDP/04539/2020 
UI/BD/154407/2022 
Serial title, monograph or event: International journal of molecular sciences
Volume: 24
Issue: 9
Abstract: Osteosarcoma is a highly malignant bone tumor derived from mesenchymal cells that contains self-renewing cancer stem cells (CSCs), which are responsible for tumor progression and chemotherapy resistance. Understanding the signaling pathways that regulate CSC self-renewal and survival is crucial for developing effective therapies. The Notch, Hedgehog, and Wnt/β-Catenin developmental pathways, which are essential for self-renewal and differentiation of normal stem cells, have been identified as important regulators of osteosarcoma CSCs and also in the resistance to anticancer therapies. Targeting these pathways and their interactions with embryonic markers and the tumor microenvironment may be a promising therapeutic strategy to overcome chemoresistance and improve the prognosis for osteosarcoma patients. This review focuses on the role of Notch, Hedgehog, and Wnt/β-Catenin signaling in regulating CSC self-renewal, pluripotency, and chemoresistance, and their potential as targets for anti-cancer therapies. We also discuss the relevance of embryonic markers, including SOX-2, Oct-4, NANOG, and KLF4, in osteosarcoma CSCs and their association with the aforementioned signaling pathways in overcoming drug resistance.
URI: https://hdl.handle.net/10316/113377
ISSN: 1422-0067
DOI: 10.3390/ijms24098401
Rights: openAccess
Appears in Collections:I&D CIBB - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais

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