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Title: Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection
Authors: Badalkhani, Omolbanin
Pires, Patrícia C. 
Mohammadi, Maryam
Babaie, Soraya
Paiva-Santos, Ana Cláudia 
Hamishehkar, Hamed
Keywords: antioxidant; cosmeceuticals; nanogel; nanostructured lipid carriers; natural-based; skin protection
Issue Date: 28-Apr-2023
Publisher: MDPI
Project: Drug Applied Research Center of Tabriz University of Medical Sciences (Grant No. 65618) 
Iran Nanotechnology Innovation Council 
Serial title, monograph or event: Pharmaceuticals
Volume: 16
Issue: 5
Abstract: The human skin is a recurring target of external aggressions, such as UV radiation, leading to exacerbation of the aging process and the occurrence of skin diseases, such as cancer. Hence, preventive measures should be taken to protect it against these aggressions, consequently decreasing the chance of disease development. In the present study, a topical xanthan gum nanogel containing gamma-oryzanol-loaded nanostructured lipid carriers (NLCs) and nanosized UV filters TiO2 and methylene bis-benzotriazolyl tetramethylbutylphenol (MBBT) was developed to assess their synergistic potential in having multifunctional skin beneficial properties. The developed NLCs contained the natural-based solid lipids shea butter and beeswax, liquid lipid carrot seed oil, and the potent antioxidant gamma-oryzanol, with an optimum particle size for topical application (<150 nm), good homogeneity (PDI = 0.216), high zeta potential (-34.9 mV), suitable pH value (6), good physical stability, high encapsulation efficiency (90%), and controlled release. The final formulation, a nanogel containing the developed NLCs and the nano UV filters, showed high long-term storage stability and high photoprotection ability (SPF = 34) and resulted in no skin irritation or sensitization (rat model). Hence, the developed formulation showed good skin protection and compatibility, demonstrating promise as a new platform for the future generation of natural-based cosmeceuticals.
ISSN: 1424-8247
DOI: 10.3390/ph16050670
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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