Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/112207
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dc.contributor.authorAmaro, Andreia-
dc.contributor.authorSousa, Diana Isabel Teixeira de-
dc.contributor.authorSá-Rocha, Mariana-
dc.contributor.authorFerreira-Junior, Marcos Divino-
dc.contributor.authorRosendo-Silva, Daniela-
dc.contributor.authorSaavedra, Lucas Paulo Jacinto-
dc.contributor.authorBarra, Cátia-
dc.contributor.authorMonteiro-Alfredo, Tamaeh-
dc.contributor.authorGomes, Rodrigo Mello-
dc.contributor.authorde Freitas Mathias, Paulo Cezar-
dc.contributor.authorBaptista, Filipa I.-
dc.contributor.authorMatafome, Paulo-
dc.date.accessioned2024-01-24T12:59:48Z-
dc.date.available2024-01-24T12:59:48Z-
dc.date.issued2023-08-15-
dc.identifier.issn2072-6643-
dc.identifier.urihttps://hdl.handle.net/10316/112207-
dc.description.abstractNutritional disturbances during the early postnatal period can have long-lasting effects on neurodevelopment and may be related to behavioural changes at adulthood. While such neuronal connection disruption can contribute to social and behaviour alterations, the dysregulation of the neuroendocrine pathways involved in nutrient-sensing balance may also cause such impairments, although the underlying mechanisms are still unclear. We aimed to evaluate sex-specific neurodevelopmental and behavioural changes upon postnatal overfeeding and determine the potential underpinning mechanisms at the central nervous system level, with a focus on the interconnection between synaptic and neuroendocrine molecular alterations. At postnatal day 3 (PND3) litters were culled to three animals (small litter procedure). Neurodevelopmental tests were conducted at infancy, whereas behavioural tests to assess locomotion, anxiety, and memory were performed at adolescence, together with molecular analysis of the hippocampus, hypothalamus, and prefrontal cortex. At infancy, females presented impaired acquisition of an auditory response, eye opening, olfactory discrimination, and vestibular system development, suggesting that female offspring neurodevelopment/maturation was deeply affected. Male offspring presented a transitory delay in locomotor performance., while both offspring had lower upper limb strength. At adolescence, both sexes presented anxious-like behaviour without alterations in short-term memory retention. Both males and females presented lower NPY1R levels in a region-specific manner. Furthermore, both sexes presented synaptic changes in the hippocampus (lower GABAA in females and higher GABAA levels in males), while, in the prefrontal cortex, similar higher GABAA receptor levels were observed. At the hypothalamus, females presented synaptic changes, namely higher vGLUT1 and PSD95 levels. Thus, we demonstrate that postnatal overfeeding modulates offspring behaviour and dysregulates nutrient-sensing mechanisms such as NPY and GABA in a sex- and brain-region-specific manner.pt
dc.language.isoengpt
dc.publisherMDPIpt
dc.relationUIDB//04539/2020pt
dc.relationUIDP//04539/2020pt
dc.relationLA/P/0058/2020: CIBBpt
dc.relationUI/BD/154406/2023pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectlactationpt
dc.subjectoverfeedingpt
dc.subjectneurodevelopmentpt
dc.subjectanxious-like behaviourpt
dc.subjectenergy balancept
dc.subjectsynaptic balancept
dc.titlePostnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-like Behaviour Accompanied by Sex- and Brain-Region-Specific Synaptic and Metabolic Changespt
dc.typearticlept
degois.publication.firstPage3581pt
degois.publication.issue16pt
degois.publication.titleNutrientspt
dc.peerreviewedyespt
dc.identifier.doi10.3390/nu15163581-
degois.publication.volume15pt
dc.date.embargo2023-08-15*
dc.identifier.pmid37630771-
uc.date.periodoEmbargo0pt
dc.identifier.eissn2072-6643-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
crisitem.author.researchunitICBR Coimbra Institute for Clinical and Biomedical Research-
crisitem.author.researchunitICBR Coimbra Institute for Clinical and Biomedical Research-
crisitem.author.researchunitICBR Coimbra Institute for Clinical and Biomedical Research-
crisitem.author.researchunitICBR Coimbra Institute for Clinical and Biomedical Research-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.parentresearchunitFaculty of Medicine-
crisitem.author.parentresearchunitFaculty of Medicine-
crisitem.author.parentresearchunitFaculty of Medicine-
crisitem.author.parentresearchunitFaculty of Medicine-
crisitem.author.orcid0000-0002-4276-5920-
crisitem.author.orcid0000-0001-5514-0797-
crisitem.author.orcid0000-0001-7972-640X-
crisitem.author.orcid0000-0002-3422-290X-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
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