Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/111953
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sousa, Tiago | - |
dc.contributor.author | Moreira, Paula I. | - |
dc.contributor.author | Cardoso, Susana | - |
dc.date.accessioned | 2024-01-17T11:03:28Z | - |
dc.date.available | 2024-01-17T11:03:28Z | - |
dc.date.issued | 2023-08-22 | - |
dc.identifier.issn | 2227-9059 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/111953 | - |
dc.description.abstract | Alzheimer's disease is the most prevalent neurodegenerative disorder and affects the lives not only of those who are diagnosed but also of their caregivers. Despite the enormous social, economic and political burden, AD remains a disease without an effective treatment and with several failed attempts to modify the disease course. The fact that AD clinical diagnosis is most often performed at a stage at which the underlying pathological events are in an advanced and conceivably irremediable state strongly hampers treatment attempts. This raises the awareness of the need to identify and characterize the early brain changes in AD, in order to identify possible novel therapeutic targets to circumvent AD's cascade of events. One of the most auspicious targets is mitochondria, powerful organelles found in nearly all cells of the body. A vast body of literature has shown that mitochondria from AD patients and model organisms of the disease differ from their non-AD counterparts. In view of this evidence, preserving and/or restoring mitochondria's health and function can represent the primary means to achieve advances to tackle AD. In this review, we will briefly assess and summarize the previous and latest evidence of mitochondria dysfunction in AD. A particular focus will be given to the recent updates and advances in the strategy options aimed to target faulty mitochondria in AD. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | The authors’ work was supported by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Program, the COMPETE 2020—Operational Programme for Competitiveness, and national funds from the FCT—Foundation for Science and Technology under the project PEst-C/SAU/LA0001/2013-2014 and strategic projects UIDB/04539/2020, UIDP/04539/2020, and LA/P/0058/2020. Cardoso, S. has a Post-Doctoral Researcher Contract DL57/2016 (#SFRH/BPD/95770/2013) from the FCT. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Alzheimer’s disease | pt |
dc.subject | glucose metabolism dysregulation | pt |
dc.subject | mitochondria | pt |
dc.subject | mitochondrialdirected approaches | pt |
dc.subject | oxidative stress | pt |
dc.title | Current Advances in Mitochondrial Targeted Interventions in Alzheimer's Disease | pt |
dc.type | article | - |
degois.publication.firstPage | 2331 | pt |
degois.publication.issue | 9 | pt |
degois.publication.title | Biomedicines | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/biomedicines11092331 | pt |
degois.publication.volume | 11 | pt |
dc.date.embargo | 2023-08-22 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0009-0006-8132-6898 | - |
crisitem.author.orcid | 0000-0001-5177-6747 | - |
crisitem.author.orcid | 0000-0002-9866-933X | - |
Appears in Collections: | IIIUC - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Current-Advances-in-Mitochondrial-Targeted-Interventions-in-Alzheimers-DiseaseBiomedicines.pdf | 1.16 MB | Adobe PDF | View/Open |
Page view(s)
37
checked on May 8, 2024
Download(s)
28
checked on May 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License