Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/111864
Title: | Measuring cognitive impairment and monitoring cognitive decline in Huntington's disease: a comparison of assessment instruments | Authors: | Horta-Barba, Andrea Martinez-Horta, Saul Pérez-Pérez, Jesús Puig-Davi, Arnau de Lucia, Natascia de Michele, Giuseppe Salvatore, Elena Kehrer, Stefanie Priller, Josef Migliore, Simone Squitieri, Ferdinando Castaldo, Anna Mariotti, Caterina Mañanes, Veronica Lopez-Sendon, Jose Luis Rodriguez, Noelia Martinez-Descals, Asunción Júlio, Filipa Januário, Cristina Delussi, Marianna de Tommaso, Marina Noguera, Sandra Ruiz-Idiago, Jesús Sitek, Emilia J Wallner, Renata Nuzzi, Angela Pagonabarraga, Javier Kulisevsky, Jaime |
Keywords: | Huntington’s disease; Cognition; Neuropsychology; Disease progression; Mild cognitive impairment; Dementia | Issue Date: | Nov-2023 | Project: | Open Access Funding provided by Universitat Autonoma de Barcelona | Serial title, monograph or event: | Journal of Neurology | Volume: | 270 | Issue: | 11 | Abstract: | Background Progressive cognitive decline is an inevitable feature of Huntington’s disease (HD) but specific criteria and instruments are still insufficiently developed to reliably classify patients into categories of cognitive severity and to monitor the progression of cognitive impairment. Methods We collected data from a cohort of 180 positive gene-carriers: 33 with premanifest HD and 147 with manifest HD. Using a specifically developed gold-standard for cognitive status we classified participants into those with normal cognition, those with mild cognitive impairment, and those with dementia. We administered the Parkinson’s Disease-Cognitive Rating Scale (PD-CRS), the MMSE and the UHDRS cogscore at baseline, and at 6-month and 12-month follow-up visits. Cutoff scores discriminating between the three cognitive categories were calculated for each instrument. For each cognitive group and instrument we addressed cognitive progression, sensitivity to change, and the minimally clinical important difference corresponding to conversion from one category to another. Results The PD-CRS cutoff scores for MCI and dementia showed excellent sensitivity and specificity ratios that were not achieved with the other instruments. Throughout follow-up, in all cognitive groups, PD-CRS captured the rate of conversion from one cognitive category to another and also the different patterns in terms of cognitive trajectories. Conclusion The PD-CRS is a valid and reliable instrument to capture MCI and dementia syndromes in HD. It captures the different trajectories of cognitive progression as a function of cognitive status and shows sensitivity to change in MCI and dementia. | URI: | https://hdl.handle.net/10316/111864 | ISSN: | 0340-5354 1432-1459 |
DOI: | 10.1007/s00415-023-11804-0 | Rights: | openAccess |
Appears in Collections: | I&D CIBIT - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Measuring-cognitive-impairment-and-monitoring-cognitive-decline-in-Huntingtons-disease-a-comparison-of-assessment-instrumentsJournal-of-Neurology.pdf | 876.65 kB | Adobe PDF | View/Open |
Page view(s)
80
checked on Oct 16, 2024
Download(s)
36
checked on Oct 16, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License