Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/111762
Title: Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice
Authors: Sousa, Adelaide
Azevedo, Rui
Costa, Vera Marisa 
Oliveira, Sara 
Preguiça, Inês 
Viana, Sofia 
Reis, Flávio 
Almeida, Agostinho 
Matafome, Paulo N. 
Dias-Pereira, Patrícia
Carvalho, Félix 
Fernandes, Eduarda
Freitas, Marisa da Silva 
Keywords: Oral intake; Biodistribution; Subacute toxicity; Intestinal inflammation; NF-кB inflammatory pathway; Cytokines and chemokines
Issue Date: Oct-2023
Publisher: Springer Nature
Project: UIBD/50006/2020 
UIDP/50006/2020 
PTDC/ NAN-MAT/29248/2017 
POCI‑01‑0145‑FEDER‑029248 
UIDB/04539/2020 
info:eu-repo/grantAgreement/UIDP/04539/2020 
LA/P/0058/2020 
SFRH/BD/150656/2020 
2020.04126.CEECIND 
LA/P/0008/2020 
metadata.degois.publication.title: Archives of Toxicology
metadata.degois.publication.volume: 97
metadata.degois.publication.issue: 10
Abstract: Silver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and the food industry. Consequently, the increased use of AgNP in the food industry has led to an unavoidable rise  in human exposure to these nanoparticles. Their widespread use raises concerns about potential hazards to human health, specifically their intestinal pro-inflammatory effects. Thus, the main objective of this study was to evaluate the biological effects of two subacute doses of 5 nm polyvinylpyrrolidone (PVP)-AgNP in C57BL/6J mice. One mg/kg body weight or 10 mg/kg bw was provided once a day for 14 days, using a new technology (HaPILLness) that allows voluntary, stress-free, and accurate oral dosing. It was observed that after oral ingestion, while AgNP is biodistributed throughout the entire organism, most of the ingested dose is excreted in the feces. The passage and accumulation of AgNP throughout the intestine instigated a prominent inflammatory response, marked by significant histological, vascular, and cellular transformations. This response was driven by the activation of the nuclear factor-кB (NF-кB) inflammatory pathway, ultimately leading to the generation of multiple cytokines and chemokines.
URI: https://hdl.handle.net/10316/111762
ISSN: 0340-5761
1432-0738
DOI: 10.1007/s00204-023-03558-5
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais

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