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Title: Fibroblast growth factor signaling in axons: from development to disease
Authors: Tomé, Diogo 
Dias, Marta S.
Correia, Joana
Almeida, Ramiro D. 
Keywords: FGF; Signaling pathways; Axons; Presynaptic terminal; Axonal injury; Neuronal disorders
Issue Date: 16-Oct-2023
Publisher: Signal Transduction Society
Project: This work was supported by “la Caixa” Foundation (ID 100010434) and FCTFundação para a Ciência e a Tecnologia, I.P. under the agreement LCF/PR/ HP20/52300001 and by FCT, I.P., under projects PTDC/NAN-OPT/7989/2020, UIDB/04501/2020, UIDP/04501/2020, UIDB/04539/2020, UIDP/04539/2020 and LA/P/0058/2020 and through the individual grants SFRH/BD/139368/2018 (D.T.), SFRH/BD/141092/2018 (M.D.) and 2021.08513.BD (J.C.). 
Serial title, monograph or event: Cell Communication and Signaling
Volume: 21
Issue: 1
Abstract: The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established roles in neuronal patterning to more recent and exciting functions in axonal growth and synaptogenesis. In addition, FGFs play a critical role in axonal regeneration, particularly after spinal cord injury, confirming their versatile nature in the nervous system. Due to their widespread involvement in neural development, the FGF system also underlies several human neurological disorders. While particular attention has been given to FGFs in a whole-cell context, their effects at the axonal level are in most cases undervalued. Here we discuss the endeavor of the FGF system in axons, we delve into this neuronal subcompartment to provide an original view of this multipurpose family of growth factors in nervous system (dys)function. Video Abstract.
ISSN: 1478-811X
DOI: 10.1186/s12964-023-01284-0
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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