Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/111166
DC FieldValueLanguage
dc.contributor.authorLaíns, Inês-
dc.contributor.authorHan, Xikun-
dc.contributor.authorGil, João-
dc.contributor.authorProvidência, Joana-
dc.contributor.authorNigalye, Archana-
dc.contributor.authorAlvarez, Rodrigo-
dc.contributor.authorDouglas, Vivian Paraskevi-
dc.contributor.authorMendez, Kevin-
dc.contributor.authorKatz, Raviv-
dc.contributor.authorTsougranis, Gregory-
dc.contributor.authorLi, Jinglun-
dc.contributor.authorKelly, Rachel S.-
dc.contributor.authorKim, Ivana K.-
dc.contributor.authorLasky-Su, Jessica-
dc.contributor.authorSilva, Rufino-
dc.contributor.authorMiller, Joan W.-
dc.contributor.authorLiang, Liming-
dc.contributor.authorVavvas, Demetrios-
dc.contributor.authorMiller, John B.-
dc.contributor.authorHusain, Deeba-
dc.date.accessioned2024-01-03T11:23:35Z-
dc.date.available2024-01-03T11:23:35Z-
dc.date.issued2024-
dc.identifier.issn26669145pt
dc.identifier.urihttps://hdl.handle.net/10316/111166-
dc.description.abstractPurpose: The most widely used classifications of age-related macular degeneration (AMD) and its severity stages still rely on color fundus photographs (CFPs). However, AMD has a wide phenotypic variability that remains poorly understood and is better characterized by OCT. We and others have shown that patients with AMD have a distinct plasma metabolomic profile compared with controls. However, all studies to date have been performed solely based on CFP classifications. This study aimed to assess if plasma metabolomic profiles are associated with OCT features commonly seen in AMD. Design: Prospectively designed, cross-sectional study. Participants: Subjects with a diagnosis of AMD and a control group (> 50 years old) from Boston, United States, and Coimbra, Portugal. Methods: All participants were imaged with CFP, used for AMD staging (Age-Related Eye Disease Study 2 classification scheme), and with spectral domain OCT (Spectralis, Heidelberg). OCT images were graded by 2 independent graders for the presence of characteristic AMD features, according to a predefined protocol. Fasting blood samples were collected for metabolomic profiling (using nontargeted high-resolution mass spectrometry by Metabolon Inc). Analyses were conducted using logistic regression models including the worst eye of each patient (AREDS2 classification) and adjusting for confounding factors. Each cohort (United States and Portugal) was analyzed separately and then results were combined by meta-analyses. False discovery rate (FDR) was used to account for multiple comparisons. Main Outcome Measures: Plasma metabolite levels associated with OCT features. Results: We included data on 468 patients, 374 with AMD and 94 controls, and on 725 named endogenous metabolites. Meta-analysis identified significant associations (FDR < 0.05) between plasma metabolites and 3 OCT features: hyperreflective foci (6), atrophy (6), and ellipsoid zone disruption (3). Most associations were seen with amino acids, and all but 1 metabolite presented specific associations with the OCT features assessed. Conclusions: To our knowledge, we show for the first time that plasma metabolites have associations with specific OCT features seen in AMD. Our results support that the wide spectrum of presentations of AMD likely include different pathophysiologic mechanisms by identifying specific pathways associated with each OCT feature.pt
dc.language.isoengpt
dc.publisherElsevierpt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subjectAge-related macular degeneration/AMDpt
dc.subjectAtrophypt
dc.subjectHyperreflective focipt
dc.subjectMetabolomicspt
dc.subjectOCTpt
dc.titlePlasma Metabolites Associated with OCT Features of Age-Related Macular Degenerationpt
dc.typearticle-
degois.publication.firstPage100357pt
degois.publication.issue1pt
degois.publication.titleOphthalmology Sciencept
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.xops.2023.100357pt
degois.publication.volume4pt
dc.date.embargo2024-01-01*
uc.date.periodoEmbargo0pt
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-8676-0833-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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This item is licensed under a Creative Commons License Creative Commons