Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/110869
DC Field | Value | Language |
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dc.contributor.author | Jacq, Laurent | - |
dc.contributor.author | Garnier, Sophie | - |
dc.contributor.author | Dieudé, Philippe | - |
dc.contributor.author | Michou, Laëtitia | - |
dc.contributor.author | Pierlot, Céline | - |
dc.contributor.author | Migliorini, Paola | - |
dc.contributor.author | Balsa, Alejandro | - |
dc.contributor.author | Westhovens, René | - |
dc.contributor.author | Barrera, Pilar | - |
dc.contributor.author | Alves, Helena | - |
dc.contributor.author | Vaz, Carlos | - |
dc.contributor.author | Fernandes, Manuela | - |
dc.contributor.author | Pascual-Salcedo, Dora | - |
dc.contributor.author | Bombardieri, Stefano | - |
dc.contributor.author | Dequeker, Jan | - |
dc.contributor.author | Radstake, Timothy R | - |
dc.contributor.author | Van Riel, Piet | - |
dc.contributor.author | van de Putte, Leo | - |
dc.contributor.author | Lopes-Vaz, Antonio | - |
dc.contributor.author | Glikmans, Elodie | - |
dc.contributor.author | Barbet, Sandra | - |
dc.contributor.author | Lasbleiz, Sandra | - |
dc.contributor.author | Lemaire, Isabelle | - |
dc.contributor.author | Quillet, Patrick | - |
dc.contributor.author | Hilliquin, Pascal | - |
dc.contributor.author | Teixeira, Vitor Hugo | - |
dc.contributor.author | Petit-Teixeira, Elisabeth | - |
dc.contributor.author | Mbarek, Hamdi | - |
dc.contributor.author | Prum, Bernard | - |
dc.contributor.author | Bardin, Thomas | - |
dc.contributor.author | Cornélis, François | - |
dc.date.accessioned | 2023-11-24T11:54:20Z | - |
dc.date.available | 2023-11-24T11:54:20Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 14786354 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/110869 | - |
dc.description.abstract | The integrin alpha(v)beta3, whose alpha(v) subunit is encoded by the ITGAV gene, plays a key role in angiogenesis. Hyperangiogenesis is involved in rheumatoid arthritis (RA) and the ITGAV gene is located in 2q31, one of the suggested RA susceptibility loci. Our aim was to test the ITGAV gene for association and linkage to RA in a family-based study from the European Caucasian population. Two single nucleotide polymorphisms were genotyped by PCR-restriction fragment length polymorphism in 100 French Caucasian RA trio families (one RA patient and both parents), 100 other French families and 265 European families available for replication. The genetic analyses for association and linkage were performed using the comparison of allelic frequencies (affected family-based controls), the transmission disequilibrium test, and the genotype relative risk.We observed a significant RA association for the C allele of rs3738919 in the first sample (affected family-based controls, RA index cases 66.5% versus controls 56.7%; P = 0.04). The second sample showed the same trend, and the third sample again showed a significant RA association. When all sets were combined, the association was confirmed (affected family-based controls, RA index cases 64.6% versus controls 58.1%; P = 0.005). The rs3738919-C allele was also linked to RA (transmission disequilibrium test, 56.5% versus 50% of transmission; P = 0.009) and the C-allele-containing genotype was more frequent in RA index cases than in controls (RA index cases 372 versus controls 339; P = 0.002, odds ratio = 1.94, 95% confidence interval = 1.3-2.9). The rs3738919-C allele of the ITGAV gene is associated with RA in the European Caucasian population, suggesting ITGAV as a new minor RA susceptibility gene. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | Association Française des Polyarthritiques, the Association de Recherche pour la Polyarthrite, the Association Polyarctique, the Association Rhumatisme et Travail, the Société Française de Rhumatologie, Genopole, the Université d'Evry- Val d'Essonne, Shering-Plough, Pfizer, Amgen, the Conseil Régional Ile de France, the Conseil Général de l' Essonne, the Ministère de la Recherche et de l'Enseignement Supérieur, the Fondation pour la Recherche Médicale, and the Centre Hospitalier Sud Francilien (France) | pt |
dc.relation | SFRH/BD/23304/2005 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Adult | pt |
dc.subject.mesh | Arthritis, Rheumatoid | pt |
dc.subject.mesh | DNA Mutational Analysis | pt |
dc.subject.mesh | Europe | pt |
dc.subject.mesh | Family Health | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Gene Frequency | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Integrin alphaV | pt |
dc.subject.mesh | Linkage Disequilibrium | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Polymerase Chain Reaction | pt |
dc.subject.mesh | White People | pt |
dc.subject.mesh | Alleles | pt |
dc.subject.mesh | Genetic Predisposition to Disease | pt |
dc.subject.mesh | Polymorphism, Single Nucleotide | pt |
dc.title | The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study | pt |
dc.type | article | - |
degois.publication.firstPage | R63 | pt |
degois.publication.issue | 4 | pt |
degois.publication.title | Arthritis Research and Therapy | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1186/ar2221 | pt |
degois.publication.volume | 9 | pt |
dc.date.embargo | 2007-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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The-ITGAV-rs3738919C-allele-is-associated-with-rheumatoid-arthritis-in-the-European-Caucasian-population-A-familybased-studyArthritis-Research-and-Therapy.pdf | 161.76 kB | Adobe PDF | View/Open |
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